Effect of consanguinity on birth weight for gestational age in a developing country

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dc.contributor.author Wakim, Gerard
dc.contributor.author Mumtaz, Ghina
dc.contributor.author Tamim, Hala
dc.contributor.author Kanaan, Mona
dc.contributor.author Khawaja, Marwan
dc.contributor.author Khogali, Mustafa
dc.date.accessioned 2018-12-20T11:05:09Z
dc.date.available 2018-12-20T11:05:09Z
dc.date.copyright 2007 en_US
dc.date.issued 2018-12-20
dc.identifier.issn 1476-6256 en_US
dc.identifier.uri http://hdl.handle.net/10725/9894
dc.description.abstract Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, consanguinity was associated with a decrease in birth weight for gestational age by 1.8% (ß = −0.018, 95% confidence interval: −0.027, −0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy. en_US
dc.language.iso en en_US
dc.title Effect of consanguinity on birth weight for gestational age in a developing country en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201000151 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Epidemiology en_US
dc.journal.volume 165 en_US
dc.journal.issue 7 en_US
dc.article.pages 742-752 en_US
dc.keywords Birth weight en_US
dc.keywords Consanguinity en_US
dc.keywords Developing countries en_US
dc.keywords Gestational age en_US
dc.keywords Lebanon en_US
dc.identifier.doi https://doi.org/10.1093/aje/kwk108 en_US
dc.identifier.ctation Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., & Yunis, K. A. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American journal of epidemiology, 165(7), 742-752. en_US
dc.author.email gerard.wakim@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://academic.oup.com/aje/article/165/7/742/158945 en_US
dc.author.affiliation Lebanese American University en_US

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