Inhibition of gram negative bacterial growth and biofilm formation by alpha thujone

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dc.contributor.author Nawas, Tarek
dc.contributor.author Mitri, Sara
dc.contributor.author Jaafar, Mohamad
dc.date.accessioned 2018-12-11T13:59:51Z
dc.date.available 2018-12-11T13:59:51Z
dc.date.copyright 2018 en_US
dc.identifier.issn 2278-3003 en_US
dc.identifier.uri http://hdl.handle.net/10725/9868
dc.description.abstract The increasing resistance of microorganism to antibiotics in the last decades, drove microbiologists, botanists, and natural-products chemists to search for phytochemicals that could be used for treatment of infectious diseases. Essential oils, which are derived from plants, such as thujone, have been recognized to display many biological activities many of which needed more exploration. This study was designed to test the ability of alpha thujone to inhibit the growth and biofilm formation of clinical bacterial isolates. The agar dilution method used to detect the antibacterial effect of alpha thujone, revealed that at high concentrations (30 mg/ml and 15 mg/ml) alpha thujone showed some antibacterial activity on some of the Gram-negative isolates tested. It was evident, however, and after using standard tests for detection of the inhibition of biofilm formation, that alpha thujone, at low concentrations (3.8 mg/ml) demonstrated an inhibitory effect on the biofilm formation of most of the different bacterial strains tested. This previously uncovered characteristic of alpha thujone, may prove to be very useful in preventing infections by primary pathogens. en_US
dc.language.iso en en_US
dc.title Inhibition of gram negative bacterial growth and biofilm formation by alpha thujone en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 198029370 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal IOSR Journal of Pharmacy and Biological Sciences en_US
dc.journal.volume 13 en_US
dc.journal.issue 2 Ver. II en_US
dc.article.pages 40-47 en_US
dc.keywords Essential oils en_US
dc.keywords Alpha thujone en_US
dc.keywords Antibacterial agents en_US
dc.keywords Bacterial biofilms en_US
dc.keywords Inhibition of biofilm formation en_US
dc.identifier.ctation Nawas, T., Mitri, D. & Jaafar M. (2018). Inhibition of Gram Negative Bacterial Growth and Biofilm Formation by Alpha Thujone. IOSR Journal of Pharmacy and Biological Sciences 13(2 ver. II), 40-47. en_US
dc.author.email tnawas@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.iosrjournals.org/iosr-jpbs/papers/Vol13-issue2/Version-2/H1302024047.pdf en_US
dc.author.affiliation Lebanese American University en_US

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