Rosmarinus officinalis leaves water extract. (c2007)

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dc.contributor.author Kashour, Bassem Mohammad
dc.date.accessioned 2011-10-31T11:35:52Z
dc.date.available 2011-10-31T11:35:52Z
dc.date.copyright 2007 en_US
dc.date.issued 2011-10-31
dc.date.submitted 2007-06-15
dc.identifier.uri http://hdl.handle.net/10725/949
dc.description Includes bibliographical references (l. 49-56). en_US
dc.description.abstract Nowadays, herbal medicine is becoming a very popular complementary therapy based on its relative safety, effectiveness, accessibility and inexpensiveness. The present study investigates the potential role of Rosmarinus officinalis leaves water extract in lipemia, glycemia, ulcer and inflammation. The antibacterial activity was also assessed on several hospital isolates. After one month of water extract intake via drinking water (200, 500 and 1000 mg/Kg body weight) the blood lipid profile and liver function of rats used during the experiment were not affected. However, the water extract (200 and 1000 mg/kg body weight) showed significant hypoglycemic and insulin-release inhibitory effects since both glucose and insulin concentrations were significantly reduced. The water extract of Rosmarinus officinalis at doses 50, 100, 250 and 500 mg/kg body weight was also studied in the rat using both acute and chronic inflammation models induced by carrageenan and formalin respectively. All dose used showed anti-inflammatory activity with significance reached at doses ≥100 mg/kg body weight in both models. The optimum dose in the acute and chronic inflammation models were 250 and 500 mg/kg body weight respectively. The anti-inflammatory effect observed was comparable to that caused by diclofenac, the control drug, in both models. Similar doses to the inflammation study were also used in the detection of anti-ulcerogenic potential of the extract. A dose dependent protection against ethanolinduced gastric ulcer was observed. However, protection became significant when rats received doses 2: 250 mglkg body weight. The 500 mg dose exhibited a protection that slightly exceeded that of the reference drug cimetril. The antibacterial effect of the water extract against 11 hospital bacterial isolates was investigated using disc diffusion technique (using a serial dilution: 200, 100, 50, 20 and 10 µg extract) and did not show any potentials in this respect. In conclusion, the water extract of R. officinalis dry leaves at the doses used has no toxic signs and symptoms and it exhibits a positive effect on ulcer, inflammation and hyperglycemia, however the extract appeared to have a neutral effect upon lipemia. en_US
dc.language.iso en en_US
dc.subject Rosemary en_US
dc.subject Herbs -- Therapeutic use en_US
dc.subject Plants, Useful en_US
dc.subject Medicinal plants en_US
dc.title Rosmarinus officinalis leaves water extract. (c2007) en_US
dc.type Thesis en_US
dc.title.subtitle A possible hypoglycemic, anti- inflammatory and anti-ulcerogenic remedy en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school Arts and Sciences en_US
dc.author.idnumber 200300790 en_US
dc.author.commembers Dr. George Baroody
dc.author.commembers Dr. Roy Khalaf
dc.author.woa OA en_US
dc.description.physdesc 1 bound copy: vi, 56 leaves; ill. (some col.); 31 cm. Available at RNL. en_US
dc.author.division Biology en_US
dc.author.advisor Dr. costantine Daher
dc.identifier.doi https://doi.org/10.26756/th.2007.47 en_US
dc.publisher.institution Lebanese American University en_US

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