Tragopogon porrifolius water extract. (c2010)

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dc.contributor.author Saab, Lea Elias
dc.date.accessioned 2011-10-27T10:21:26Z
dc.date.available 2011-10-27T10:21:26Z
dc.date.copyright 2010 en_US
dc.date.issued 2011-10-27
dc.date.submitted 2010-06-01
dc.identifier.uri http://hdl.handle.net/10725/932
dc.description Includes bibliographical references (leaves 36-42). en_US
dc.description.abstract Tragopogon porrifolius (Purple salsify) is commonly known as the oyster plant or vegetable oyster. It is cultivated for its florid flower, edible root and shoot, and herbal qualities. The present research project investigates the effects of the water extract of Tragopogon porrifolius shoot upon lipemia, glycemia, inflammation, oxidative stress, hepatotoxicity and gastric ulcer using a rat model. After one month of Tragopogon porrifolius water extract intake (50, 100 and 250 mg/kg body weight) via drinking water, animals exhibited a significant decrease in the levels of serum cholesterol, triglyceride, glucose and liver enzyme (ALP, ALT, LDH). Pretreatment of the rats with the extract at 50, 100 and 250 mg/kg body weight demonstrated strong anti-inflammatory effects in both acute (51, 82, 92%) and chronic (18, 59, 85%) inflammation induced by carrageenan and formalin respectively. The extract also showed effective anti-ulcerogenic property (42, 64 and 76%) against ethanol induced gastric ulcer. Consistent dose dependent protection against paracetamol induced toxicity was observed after testing the serum levels of ALT, ALP, AST and LDH. Tragopogon porrifolius also revealed effective anti-oxidant capacity due to its notable scavenging activity against 2, 2-diphenyl-1- picrylhydrazyl (DPPH) radicals (81 %). In conclusion, it can be inferred that Tragopogon porrifolius provides a potential source of therapeutic herbal supplements. en_US
dc.language.iso en en_US
dc.subject Salsify en_US
dc.subject Materia medica, Vegetable en_US
dc.title Tragopogon porrifolius water extract. (c2010) en_US
dc.type Thesis en_US
dc.title.subtitle A potential remedy for hyperlipidemia, hepatotoxicity, inflammation & gastric ulcer en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school Arts and Sciences en_US
dc.author.idnumber 200803624 en_US
dc.author.commembers Dr. Mohamad Mroueh
dc.author.commembers Dr. Brigitte Wex
dc.author.woa OA en_US
dc.description.physdesc 1 bound copy: vii, 42 leaves; col. ill.; 30 cm. Available at RNL. en_US
dc.author.division Biology en_US
dc.author.advisor Dr. Costantine Daher
dc.identifier.doi https://doi.org/10.26756/th.2010.49 en_US
dc.publisher.institution Lebanese American University en_US

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