Nasturtium officinalis water extract. (c2009)

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dc.contributor.author Fares, Najwan
dc.date.accessioned 2011-10-25T11:09:14Z
dc.date.available 2011-10-25T11:09:14Z
dc.date.copyright 2009 en_US
dc.date.issued 2011-10-25
dc.date.submitted 2009-05
dc.identifier.uri http://hdl.handle.net/10725/895
dc.description Includes bibliographical references (l.41-49). en_US
dc.description.abstract Nasturtium officinalis plants, commonly known as Watercress, or Habb Ar Rashad in Arabic, possess a wide range of biological activities. Although not many studies were conducted on Watercress, research is still in progress about this plant because of its well known medicinal value in folk medicine throughout the world and especially in the Arab countries. The present study explores the effects of the water extract of Nasturtium officinalis upon rat blood lipid profile, glycemia, liver enzymes, gastric ulcer, inflammation and antioxidant activity. After one month of chronic extract intake of N.ojjicinalis water extract (100, 2S0 and SOO mg/kg body weight) via drinking water, rats showed no significant changes in the serum total cholesterol, HDL cholesterol and triglyceride levels. Similarly, the glucose level was not significantly different from the control group. Extract intake did not appear to affect stool triglyceride and water content. However a significant decrease in stool cholesterol was observed with the lowest dose. The 100 and 2S0 mg/kg body weight doses showed a decrease in body weight. Liver enzyme activities (ALT, ALP, AST) were not negatively affected thus assuring that the extract has no hepatotoxic effects over the study period. Extract at 100, 2S0, and 500mg/kg body weight exhibited substantial anti-inflammatory effects in cases of acute and chronic inflammation induced by carrageenan and formalin respectively. Pre-treatment of fasted rats with the extract (l00 and 2S0mg/kg body weight) also demonstrated significant protection against ethanol-induced gastric ulcer. N officinalis also exhibited a strong scavenging activity against DPPH radicals (55 %) and the ferric reducing antioxidant power (FRAP) value was 1085/-lmol/g. The content of phenolic compound in the extract assessed by Folin-Ciocalteu reagent was 820 mg galic acid equivalent/ g and gave a high phenolic compound content. In conclusion, these investigations suggest that the water extract of Nasturtium officinalis is an easy, inexpensive remedy used to treat various conditions that affect the human well-being. en_US
dc.language.iso en en_US
dc.subject Watercress -- Therapeutic use en_US
dc.subject Anti-inflammatory agents en_US
dc.subject Anti-Ulcer Agents en_US
dc.subject Antioxidants en_US
dc.subject Plants, Useful -- Therapeutic use en_US
dc.subject Medicinal plants en_US
dc.title Nasturtium officinalis water extract. (c2009) en_US
dc.type Thesis en_US
dc.title.subtitle A potential anti-Inflammatory, anti-ulcerogenic and antioxidant remedy en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school Arts and Sciences en_US
dc.author.idnumber 200600210 en_US
dc.author.commembers Dr. Mohamad Mroueh
dc.author.commembers Dr. George Baroody
dc.author.woa OA en_US
dc.description.physdesc 1 bound copy: x, 49 leaves; col. ill.; 31 cm. Available at RNL. en_US
dc.author.division Biology en_US
dc.author.advisor Dr. Costantine Daher
dc.identifier.doi https://doi.org/10.26756/th.2009.50 en_US
dc.publisher.institution Lebanese American University en_US

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