Lactic acid mediates the effects of physical exercise on learning and memory through SIRT1-dependent activation of hippocampal BDNF. (c2018)

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dc.contributor.author Hayek, Lauretta El
dc.date.accessioned 2018-10-02T09:33:08Z
dc.date.available 2018-10-02T09:33:08Z
dc.date.copyright 2018 en_US
dc.date.issued 2018-10-02
dc.date.submitted 2018-03-02
dc.identifier.uri http://hdl.handle.net/10725/8547
dc.description.abstract Exercise promotes learning and memory formation. These effects are dependent in part on increases in hippocampal BDNF, a growth factor associated with cognitive improvement and the alleviation of depression symptoms. Identifying molecules that are produced during exercise and that mediate induction of Bdnf gene expression in the hippocampus will allow us to harness the therapeutic potential of exercise. Here, we report that an endogenous molecule produced during exercise induces the Mus musculus Bdnf gene and promotes learning and memory formation. The metabolite lactate, which is increased during exercise, induces Bdnf expression and TRKB signaling in the hippocampus. Indeed, we find that lactate-dependent increases in hippocampal BDNF are associated with improved spatial learning and memory retention. The action of lactate is dependent on the activation of the Sirtuin1 deacetylase. SIRT1 increases the levels of the transcriptional coactivator PGC1a and the secreted molecule FNDC5, previously shown to mediate Bdnf expression. These results reveal an endogenous mechanism to explain how physical exercise leads to the induction of BDNF, and identify lactate as a potential endogenous molecule that may have therapeutic value for central nervous system diseases in which BDNF signaling is disrupted. en_US
dc.language.iso en en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.subject Exercise therapy en_US
dc.subject Memory -- Physiological aspects en_US
dc.subject Learning -- Physiological aspects en_US
dc.subject Hippocampus (Brain) en_US
dc.subject Lactic acid en_US
dc.title Lactic acid mediates the effects of physical exercise on learning and memory through SIRT1-dependent activation of hippocampal BDNF. (c2018) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201202099 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Tokajian, Sima
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: ix, 57 leaves; col. ill.; 30 cm. available at RNL. en_US
dc.author.advisor Sleiman, Sama F.
dc.keywords Lactic acid en_US
dc.keywords Physical Exercise en_US
dc.keywords Hippocampus en_US
dc.keywords BDNF en_US
dc.keywords Sirtuins en_US
dc.keywords Learning en_US
dc.keywords Memory en_US
dc.description.bibliographiccitations Bibliography : leaves 41-57. en_US
dc.identifier.doi https://doi.org/10.26756/th.2018.73 en_US
dc.author.email lauretta.elhayek@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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