Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018)

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dc.contributor.author Dennaoui, Rayane
dc.date.accessioned 2018-10-02T08:47:02Z
dc.date.available 2018-10-02T08:47:02Z
dc.date.copyright 2018 en_US
dc.date.issued 2018-10-02
dc.date.submitted 2018-04-18
dc.identifier.uri http://hdl.handle.net/10725/8543
dc.description.abstract Malignant gliomas remain a medical concern in oncology due to their high morbidity rates and their aggressive behavior in the invasion of normal brain parenchyma. It has been a challenge to cure these types of brain tumors owing to the importance of the brain in regulating a plethora of human physiological functions, chemotherapy resistance, and inefficient surgical resection. Cell motility and invasion are patterns of glioma spreading and are multifaceted processes involving dynamic changes in the actin cytoskeleton. Major regulators that orchestrate actin reorganization and migration are members of the Rho family of GTPases. In this study, we investigate the contribution of two structurally similar Rho proteins, RhoA and RhoC, in glioma migration and invasion. One of our objectives was to explore the effects of both RhoA and RhoC on two- dimensional motility. Our data suggest that both proteins are positive regulators and enhancers of cell migration, adhesion to the extracellular matrix, and protrusion formation through the regulation of actin cytoskeletal dynamics. Another objective for the study was to study the differential roles of RhoA and RhoC in invasion and invadopodia assembly. We have found that RhoC is the main driver of the process in astrocytomas. In addition, we investigated possible cross-talks between RhoA, RhoC, Cdc42, and Rac1. Our data suggest that RhoA and RhoC downregulate both Rac1 and Cdc42 in order to achieve their roles in motility and invasion. en_US
dc.language.iso en en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.subject Cells -- Motility en_US
dc.subject Microbial invasiveness en_US
dc.subject Cell membranes -- Formation en_US
dc.subject Astrocytomas en_US
dc.subject GTPase-activating protein en_US
dc.title Distinctive roles of RhoA and RhoC in glioma cell motility, invasion, and invadopodia assembly. (c2018) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201100287 en_US
dc.author.commembers Sabbagh, Michella Ghassibe
dc.author.commembers Tokajian, Sima
dc.author.department Natural Sciences en_US
dc.description.embargo 2020-04-18 en_US
dc.description.physdesc 1 hard copy: xvi, 70 leaves; col. ill.; 30 cm. available at RNL. en_US
dc.author.advisor El Sibai, Mirvat
dc.keywords RhoA en_US
dc.keywords RhoC en_US
dc.keywords invadopodia en_US
dc.keywords focal adhesions en_US
dc.keywords astrocytoma en_US
dc.keywords motility en_US
dc.description.bibliographiccitations Bibliography : leaves 59-70. en_US
dc.identifier.doi https://doi.org/10.26756/th.2018.72 en_US
dc.author.email rayane.dennaoui@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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