STARD 13 in prostate cancer. (c2018)

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dc.contributor.author Saab, Sahar S.
dc.date.accessioned 2018-10-01T09:24:18Z
dc.date.available 2018-10-01T09:24:18Z
dc.date.copyright 2018 en_US
dc.date.issued 2018-10-01
dc.date.submitted 2018-05-14
dc.identifier.uri http://hdl.handle.net/10725/8529
dc.description.abstract Prostate cancer is the most commonly diagnosed solid organ tumor and one of the main leading causes of death – due to cancerous tumors- among men in the world. Malignancy of a tumor is characterized by the rapid and uncontrolled growth and its ability to metastasize. Proliferation and migration are known to be regulated by Rho family of GTPases. StarD13 is a GAP for Rho GTPases and has been previously described to be a tumor suppressor in astrocytoma, breast and colorectal cancer. In this study, we investigate the role of StarD13, an inhibitor of RhoA and Cdc42 through its GAP activity, on prostate cancer cells proliferation and metastasis by manipulating its level of expression in the cells. Knocking down StarD13 by siRNA led to an increase in cell proliferation and adhesion yet a decrease in cell motility and cell speed in prostate cancer. The activation levels of CDC42 following StarD13 knockdown are also being investigated through FRET. Our data showed that StarD13 knockdown had no significant effect on prostate cancer cell invasion; further investigations are to be accomplished in order to discover the reasons behind this insignificance. en_US
dc.language.iso en en_US
dc.subject Prostate -- Cancer -- Research en_US
dc.subject Cancer cells -- Growth -- Regulation en_US
dc.subject Antioncogenes en_US
dc.subject GTPase-activating protein en_US
dc.title STARD 13 in prostate cancer. (c2018) en_US
dc.type Thesis en_US
dc.title.subtitle a shining star or an oncogene? en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201202804 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Tokajian, Sima
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: xiii, 38 leaves; col. ill.; 30 cm. available at RNL. en_US
dc.author.advisor El Sibai, Mirvat
dc.keywords StarD13 en_US
dc.keywords Rho GTPases en_US
dc.keywords GAP en_US
dc.keywords RhoA en_US
dc.keywords CDC42 en_US
dc.keywords Prostate Cancer en_US
dc.keywords Metastasis en_US
dc.keywords Motility en_US
dc.keywords Invasion en_US
dc.keywords Adhesion en_US
dc.keywords FRET en_US
dc.description.bibliographiccitations Bibliography : leaves 35-38. en_US
dc.identifier.doi https://doi.org/10.26756/th.2018.62 en_US
dc.author.email sahar.saab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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