Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum

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dc.contributor.author Taleb, RI
dc.contributor.author Daher, C.
dc.contributor.author Mroueh, M.
dc.contributor.author Mansour, A
dc.contributor.author Shehaby, W
dc.contributor.author Diab-Assaf, M
dc.date.accessioned 2018-09-06T08:59:57Z
dc.date.available 2018-09-06T08:59:57Z
dc.date.copyright 2012 en_US
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/8426
dc.description.abstract Phenolic and flavonoid contents, antioxidant and anticancer activities of the methanolic, chloroform and ethyl acetate extracts of Arum Palaestinum were evaluated. The highest phenolic (mg gallic acid equiv./g dry extract) and flavonoid (mg quercetin equiv./g dry extract) contents were observed in the methanolic (30. 9±0.2; 14.4±0.8), followed by chloroform (13.7±0.6; 11.9±0.9) and ethyl acetate (5.3±0.6; 8.5±0.8) extracts, respectively. The FRAP and DPPH antioxidant activities were highly correlated with the phenolic's and flavonoid's contents. The antiproliferative effects of the extracts were evaluated against the T cell lymphoblastic leukemia, Jurkat cells at 24 and 48 hr. Results showed a dose dependent reduction in cell proliferation, with more significance at 48 hrs. The IC50 values were (17.5±2.1µg/mL), (19.7±2.8µg/mL) and (23.3±2.8µg/mL) for ethyl acetate, methanol and chloroform extracts, respectively at non-cytotoxic concentrations. The present data suggests a lack of correlation between antioxidant and anticancer activities and further investigation is needed to elucidate the mechanism of action involved and to identify the active components. en_US
dc.language.iso en en_US
dc.title Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200901968 en_US
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 78 en_US
dc.journal.issue 11 en_US
dc.article.pages PI389 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0032-1321076 en_US
dc.identifier.ctation Diab-Assaf, M., Taleb, R. I., Shebaby, W., Mansour, A., Moussa, C. J., Daher, C., & Mroueh, M. (2012). Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum. Planta Medica, 78(11), PI389. en_US
dc.author.email robin.taleb@lau.edu.lb en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076 en_US
dc.orcid.id https://orcid.org/0000-0001-8033-6951 en_US
dc.author.affiliation Lebanese American University en_US

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