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Effect of dietary protein level on gentamicininduced nephrotoxicity in rats and on the circadian rhythms of food ingestion

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dc.contributor.author Zeeni, Nadine
dc.date.accessioned 2018-09-03T10:42:39Z
dc.date.available 2018-09-03T10:42:39Z
dc.date.copyright 2006 en_US
dc.identifier.uri http://hdl.handle.net/10725/8414
dc.description.abstract All aminoglycosides have the potential to cause nephrotoxicity. Previous studies have shown that this toxicity was altered according to the macronutrient composition of dietary regimens offered to female rats. In a first study, adult female Sprague-Dawley rats adapted to a standard chow diet, the standard chow with 20% added casein or with 55% added casein were treated for 10 days with a nephrotoxic dose of gentamicin sulfate (40 mg/kg/day, i.p.) or a saline solution. Food ingestion patterns and gentamicin nephrotoxicity indices were measured. In a second study, rats were fed the same diets, however, the treatment given was a sham injection. Results suggest that chronic gentamicin treatment leads to a decrease in food intake and flattening of the rhythms of food ingestion. Also, chow feeding and chow added with 20% casein were found to be more protective against gentamicin-induced nephrotoxicity than chow added with 55% casein. en_US
dc.language.iso en en_US
dc.subject Nephrotoxicology -- Nutritional aspects en_US
dc.title Effect of dietary protein level on gentamicininduced nephrotoxicity in rats and on the circadian rhythms of food ingestion en_US
dc.type Thesis en_US
dc.author.degree MS in Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201000400 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.author.advisor Thibault, Louise
dc.description.bibliographiccitations Includes bibliographical references en_US
dc.identifier.ctation Zeeni, N. (2007). Effects of Dietary Protein Level on Gentamicin-induced Nephrotoxicity in Rats and on the Circadian Rhythms of Food Ingestion. ProQuest. en_US
dc.author.email nadine.zeeni@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.identifier.url http://digitool.library.mcgill.ca/R/?func=dbin-jump-full&object_id=98528&local_base=GEN01-MCG02 en_US
dc.publisher.institution McGill University en_US
dc.author.affiliation Lebanese American University en_US


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