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Biodistribution and scintigraphic evaluation of microemulsion formulations of technetium-99m-radiolabeled-thymoquinone

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dc.contributor.author Elaridi, Jomana
dc.contributor.author Japtap, Aarti
dc.contributor.author Velho-Pereira, Reelma
dc.date.accessioned 2018-08-30T12:55:08Z
dc.date.available 2018-08-30T12:55:08Z
dc.date.copyright 2017 en_US
dc.identifier.issn 0975-7384 en_US
dc.identifier.uri http://hdl.handle.net/10725/8404
dc.description.abstract The hydrophobic nature of thymoquinone (TQ) compromises its bioavailability and limits its effectiveness as an anticancer compound. The preparation and evaluation of TQ-microemulsion formulations was investigated. Parenteral and oral formulations of TQ-microemulsions were prepared by studying the solubility of TQ in different oils, surfactants and co-surfactants and investigating their stability, globule size, zeta potential, and in vitro and in vivo activity by scintigraphic evaluation of the technetium-99m-radiolabelled TQ-microemulsions. The mean globule size of the TQ-micremulsions was on the nanometer scale. The mean size of the oral formulation remained constant in distilled water and in buffers of various pH for 6 h, while the parenteral formulation was found to be stable for 72 h in distilled water and various aqueous solutions. The in vitro anticancer activity of the TQ formulations against MCF7 and Wehi 164 cell lines was evaluated and determined to be superior to plain TQ. Relative tumor volumes (RTV) of mice transplanted with MCF cells after oral and intravenous administration of TQ-microemulsions were measured to be 6 and 73.2 mm 3 respectively compared to 21.1 nd 231 mm 3 for administration of plain TQ. Similarly, mice transplanted with murine fibrosarcoma cells had RTVs of 68 and 175.3 mm 3 after oral and parenteral administration of TQ-microemulsions compared to 190.1 and 214 mm 3 for analogous administration of plain TQ. Our study is the first to describe the preparation, scintigraphic evaluation and biodistribution of TQ-microemulsion formulations. The superior properties of the microemulsion formulations potentiate their future use in the treatment of solid tumors. en_US
dc.language.iso en en_US
dc.title Biodistribution and scintigraphic evaluation of microemulsion formulations of technetium-99m-radiolabeled-thymoquinone en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201100947 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Chemical and Pharmaceutical Research en_US
dc.journal.volume 9 en_US
dc.journal.issue 9 en_US
dc.article.pages 188-198 en_US
dc.keywords 99mTc-thymoquinone en_US
dc.keywords Biodistribution en_US
dc.keywords Radiolabeling en_US
dc.keywords Scintigraphy en_US
dc.keywords Microemulsions en_US
dc.keywords Formulation en_US
dc.identifier.ctation Velho-Pereira, R., Japtap, A., & Elaridi, J. (2014). Biodistribution and Scintigraphic Evaluation of Microemulsion Formulations of Technetium-99m-Radiolabeled-Thymoquinone, 9(9), 188-198. en_US
dc.author.email jomana.aridi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.researchgate.net/publication/320711101_Biodistribution_and_Scintigraphic_Evaluation_of_Microemulsion_Formulations_of_Technetium-99m-Radiolabeled-Thymoquinone en_US
dc.author.affiliation Lebanese American University en_US


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