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Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone

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dc.contributor.author Elaridi, Jomana
dc.date.accessioned 2018-08-30T11:24:28Z
dc.date.available 2018-08-30T11:24:28Z
dc.date.copyright 2017 en_US
dc.identifier.issn 1307-6175 en_US
dc.identifier.uri http://hdl.handle.net/10725/8398
dc.description.abstract Naphthoquinones have been reported to possess a variety of pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic and anticancer effects. We have successfully synthesized a series of novel naphthoquinone acylhydrazides. The straightforward synthesis of these molecules involves a coupling reaction between 2,3-dichloro-1,4-naphthoquinone and several alkyl and aromatic hydrazides and the hydrazides of the pyrimidine nucleobases, uracil and thymine. The product hydrazides were isolated in good yields and completely characterized by spectroscopic analysis. Biological evaluation against human colon cancer HCT116 cells and human breast cancer MCF-7 cells indicated that the novel hydrazides possessed significant anticancer activity. en_US
dc.language.iso en en_US
dc.title Preparation and biological evaluation of novel acylhydrazide derivatives of 2,3-dichloronaphthoquinone en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201100947 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Organic commincations en_US
dc.journal.volume 10 en_US
dc.journal.issue 2 en_US
dc.article.pages 122-129 en_US
dc.keywords Acylhydrazide en_US
dc.keywords 1,4-napththoquinone-2-acyl hydrazides en_US
dc.keywords 2,3-dichloro-1,4-naphthoquinone en_US
dc.keywords Pyrimidine nucleobase en_US
dc.identifier.ctation Elaridi, J., Karroum, N. B., Bouhadir, K., & Fatfat, M. (2017). Preparation and biological evaluation of novel acylhydrazide derivatives of 2, 3-dichloronaphthoquinone. Organic Communications, 10(2), 122. en_US
dc.author.email jomana.aridi@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.researchgate.net/profile/Jomana_Elaridi/publication/317254349_Preparation_and_biological_evaluation_of_novel_acylhydrazide_derivatives_of_23-dichloronaphthoquinone/links/593c4f3d458515e398168db5/Preparation-and-biological-evaluation-of-novel-acylhydrazide-derivatives-of-2-3-dichloronaphthoquinone.pdf en_US
dc.author.affiliation Lebanese American University en_US


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