Combinatory effect of diet and exercise on brain derived neurotrophic factor expression, cognitive function and behavioral phenotypes of psychiatric disorders. (c2017)

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dc.contributor.author Abou Haidar, Edwina T.
dc.date.accessioned 2018-07-10T08:36:49Z
dc.date.available 2018-07-10T08:36:49Z
dc.date.copyright 2017 en_US
dc.date.issued 2018-07-10
dc.date.submitted 2017-12-19
dc.identifier.uri http://hdl.handle.net/10725/8182
dc.description.abstract Psychiatric diseases are characterized by varying forms of cognitive impairment. Human and mouse Brain Derived Neurotropic Factor (BDNF) levels are altered in psychiatric diseases, and BDNF signaling not only contributes to the pathophysiology of depression, but also is important for the therapeutic effects of antidepressants. Its involvement in the learning processes and memory formation has also been well established. BDNF levels are dramatically decreased in the adult brain in response to stress and are elevated by increased exercise. Furthermore, exercise induces beneficial responses in the brain, many of which are mediated through induction of Bdnf expression. In this work, we aim to study the effect of combining different diets with voluntary exercise on Bdnf expression and in turn on learning, memory and amelioration of depression symptoms. The overall hypothesis is that determining how exercise and different diets coordinate to induce Bdnf gene expression will identify novel therapeutic targets for depression and lifestyle adjustments that may prevent depression. We have found that combining a high protein diet with exercise has an additive effect on the induction of brain Bdnf expression. We have also identified the branched chain amino acid leucine to be a crucial amino acid involved in BDNF induction. The branch chain amino acids, leucine, isoleucine and valine had very modest effects on improvement of learning and memory. However, leucine, isoleucine and valine rescued behavioral phenotypes in a chronic social defeat mouse model and promoted resilience to stress. en_US
dc.language.iso en en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.subject Mental illness -- Treatment en_US
dc.subject Diet therapy en_US
dc.subject Brain -- Physiology en_US
dc.subject Exercise -- Physiological aspects en_US
dc.title Combinatory effect of diet and exercise on brain derived neurotrophic factor expression, cognitive function and behavioral phenotypes of psychiatric disorders. (c2017) en_US
dc.type Thesis en_US
dc.term.submitted Fall en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201101797 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Abi Habib, Ralph
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: x, 70 leaves; 30 cm. available at RNL. en_US
dc.author.advisor Sleiman, Sama F.
dc.keywords BDNF en_US
dc.keywords Exercise en_US
dc.keywords Diet en_US
dc.keywords High-protein Diet en_US
dc.keywords Branched-Chain Amino Acids en_US
dc.keywords Leucine en_US
dc.keywords Isoleucine en_US
dc.keywords Valine en_US
dc.keywords Depression en_US
dc.description.bibliographiccitations Bibliography : leaves 56-70. en_US
dc.identifier.doi https://doi.org/10.26756/th.2018.60 en_US
dc.author.email edwina.abouhaidar@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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