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Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon

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Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon

Tokajian, Sima; Salloum, Tamara; Eisen, Jonathan E.; Jospin, Guillaume; Farra, Anna; Mokhbat, Jacques E.; Coil, David A.
URI: http://hdl.handle.net/10725/8092
URL: https://www.futuremedicine.com/doi/abs/10.2217/fmb-2017-0171
DOI: https://doi.org/10.2217/fmb-2017-0171
Date: 2018-06-25
Terms of Use: This item is made available under the terms and conditions applicable to " Article ", as set forth at: http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php

Abstract:

Aim: Extended-spectrum β-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs. Materials & methods: Samples were isolated from patients admitted for gastrointestinal and urological procedures at the University Medical Center-Rizk Hospital (UMCRH) in Lebanon. Illumina paired-end libraries were prepared and sequenced. Results: The isolates were distributed into five lineages: ST131, ST648, ST405, ST73 and ST38, and harbored blaOXA-1, blaTEM-1B, blaTEM-1C and aac(6′)Ib-cr. ST131 isolates were carriers of stx2 converting I phage. Conclusion: This is the first comprehensive genomic analysis performed on ESBLs in Lebanon.

Citation:

Tokajian, S., Salloum, T., Eisen, J. A., Jospin, G., Farra, A., Mokhbat, J. E., & Coil, D. A. (2017). Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon. Future microbiology, 12(3), 213-226.

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