Origin and evolution of European community-acquired methicillin-resistant staphylococcus aureus

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dc.contributor.author Tokajian, Sima
dc.contributor.author Stegger, Marc
dc.contributor.author Wirth, Thierry
dc.contributor.author Andersen, Paal S.
dc.date.accessioned 2018-06-25T09:50:36Z
dc.date.available 2018-06-25T09:50:36Z
dc.date.copyright 2014 en_US
dc.date.issued 2018-06-25
dc.identifier.issn 2150-7511 en_US
dc.identifier.uri http://hdl.handle.net/10725/8091
dc.description.abstract Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was recognized in Europe and worldwide in the late 1990s. Within a decade, several genetically and geographically distinct CA-MRSA lineages carrying the small SCCmec type IV and V genetic elements and the Panton-Valentine leukocidin (PVL) emerged around the world. In Europe, the predominant CA-MRSA strain belongs to clonal complex 80 (CC80) and is resistant to kanamycin/amikacin and fusidic acid. CC80 was first reported in 1993 but was relatively rare until the late 1990s. It has since been identified throughout North Africa, the Middle East, and Europe, with recent sporadic reports in sub-Saharan Africa. While strongly associated with skin and soft tissue infections, it is rarely found among asymptomatic carriers. Methicillin-sensitive S. aureus (MSSA) CC80 strains are extremely rare except in sub-Saharan Africa. In the current study, we applied whole-genome sequencing to a global collection of both MSSA and MRSA CC80 isolates. Phylogenetic analyses strongly suggest that the European epidemic CA-MRSA lineage is derived from a PVL-positive MSSA ancestor from sub-Saharan Africa. Moreover, the tree topology suggests a single acquisition of both the SCCmec element and a plasmid encoding the fusidic acid resistance determinant. Four canonical SNPs distinguish the derived CA-MRSA lineage and include a nonsynonymous mutation in accessory gene regulator C (agrC). These changes were associated with a star-like expansion into Europe, the Middle East, and North Africa in the early 1990s, including multiple cases of cross-continent imports likely driven by human migrations en_US
dc.language.iso en en_US
dc.title Origin and evolution of European community-acquired methicillin-resistant staphylococcus aureus en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 199736770 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal mBio en_US
dc.journal.volume 5 en_US
dc.journal.issue 5 en_US
dc.article.pages 1-12 en_US
dc.identifier.doi http://dx.doi.org/10.1128/mBio.01044-14 en_US
dc.identifier.ctation Stegger, M., Wirth, T., Andersen, P. S., Skov, R. L., De Grassi, A., Simões, P. M., ... & Cirković, I. (2014). Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus. MBio, 5(5), 1-12. en_US
dc.author.email stokajian@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://mbio.asm.org/content/5/5/e01044-14.short en_US
dc.author.affiliation Lebanese American University en_US

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