Parallel genetic algorithm for disease-gene association

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dc.contributor.author Mansour, Nashat
dc.contributor.author Mouawad, A.E.
dc.date.accessioned 2018-05-17T11:06:02Z
dc.date.available 2018-05-17T11:06:02Z
dc.date.copyright 2011 en_US
dc.identifier.uri http://hdl.handle.net/10725/7853
dc.description.abstract After revealing the complete human genome, computational biology shifted towards the study of associations between complex diseases and genetic markers. Given that the number of human DNA variations, called single nucleotide polymorphisms (SNPs), account for a small percentage of the whole genome, accurate and informative results have become possible. However, a major limitation in association studies is the cost of genotyping SNPs. Therefore, finding a small subset of tag SNPs to be used as good representatives of the rest of the SNPs is essential. In this work, we combine few successful strategies from the literature and present a parallel genetic algorithm for the Tag SNP Selection problem. Our results compared favorably with those of a recognized tag SNP selection algorithm using three different data sets from the HapMap project. en_US
dc.language.iso en en_US
dc.publisher IEEE Xplore en_US
dc.title Parallel genetic algorithm for disease-gene association en_US
dc.type Conference Paper / Proceeding en_US
dc.author.school SAS en_US
dc.author.idnumber 198629170 en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.keywords Disease-gene association en_US
dc.keywords Genetic algorithms en_US
dc.keywords Single nucleotide polymorphism en_US
dc.keywords Tag SNP en_US
dc.identifier.doi http://dx.doi.org/10.1109/ICNC.2011.6022409 en_US
dc.identifier.ctation Mouawad, A. E., & Mansour, N. (2011, July). Parallel genetic algorithm for disease-gene association. In Natural Computation (ICNC), 2011 Seventh International Conference on (Vol. 4, pp. 2215-2219). IEEE. en_US
dc.author.email nmansour@lau.edu.lb en_US
dc.conference.date 26-28 July 2011 en_US
dc.conference.pages 2215-2219 en_US
dc.conference.place Shanghai, China en_US
dc.conference.title 2011 Seventh International Conference on Natural Computation (ICNC) en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://ieeexplore.ieee.org/abstract/document/6022409/ en_US
dc.orcid.id https://orcid.org/0000-0002-3603-8284 en_US
dc.author.affiliation Lebanese American University en_US

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