Scatter search for homology modeling

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dc.contributor.author Mansour, Nashat
dc.contributor.author Stamboulian, Mouses
dc.date.accessioned 2018-05-17T08:17:53Z
dc.date.available 2018-05-17T08:17:53Z
dc.date.copyright 2016 en_US
dc.identifier.uri http://hdl.handle.net/10725/7838
dc.description.abstract Homology modeling is an effective technique in protein structure prediction (PSP). However this technique suffers from poor initial target-template alignments. To improve homology based PSP, we propose a scatter search (SS) metaheuristic algorithm. SS is an evolutionary approach that is based on a population of candidate solutions. These candidates undergo evolutionary operations that combine search intensification and diversification over a number of iterations. The metaheuristic optimizes the initial poor alignments and uses fitness functions. We assess our algorithm on a number of proteins whose structures are present in the Protein Data Bank and which have been used in previous literature. Results obtained by our SS algorithm are compared with other approaches. The 3D models predicted by our algorithm show improved root mean standard deviations with respect to the native structures. en_US
dc.language.iso en en_US
dc.publisher Springer en_US
dc.title Scatter search for homology modeling en_US
dc.type Conference Paper / Proceeding en_US
dc.author.school SAS en_US
dc.author.idnumber 198629170 en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.keywords Comparative modeling en_US
dc.keywords Homology modeling en_US
dc.keywords Protein structure prediction en_US
dc.keywords Scatter search en_US
dc.keywords Metaheuristics en_US
dc.identifier.doi http://dx.doi.org/10.1007/978-3-319-41000-5_7 en_US
dc.identifier.ctation Stamboulian, M., & Mansour, N. (2016, June). Scatter Search for Homology Modeling. In International Conference in Swarm Intelligence (pp. 66-73). Springer, Cham. en_US
dc.author.email nmansour@lau.edu.lb en_US
dc.conference.date June 25-30, 2016 en_US
dc.conference.pages 66-73 en_US
dc.conference.place Bali, Indonesia en_US
dc.conference.title 7th International Conference in Swarm Intelligence en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/chapter/10.1007/978-3-319-41000-5_7 en_US
dc.orcid.id https://orcid.org/0000-0002-3603-8284 en_US
dc.author.affiliation Lebanese American University en_US
dc.title.volume Advances in Swarm Intelligence en_US

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