Phosphorus supplementation increases thermic response to glucose solution in healthy lean subjects

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dc.contributor.author Bassil, Maya
dc.contributor.author Zeeni, Nadine
dc.contributor.author Obeid, Omar
dc.date.accessioned 2018-05-10T09:38:25Z
dc.date.available 2018-05-10T09:38:25Z
dc.date.copyright 2013 en_US
dc.date.issued 2018-05-10
dc.identifier.issn 1530-6860 en_US
dc.identifier.uri http://hdl.handle.net/10725/7798
dc.description.abstract Thermic effect of food (TEF) is believed to be largely related to ATP production that is known to depend on phosphorus (P) availability. We hypothesised that the addition of P to a glucose load would enhance ATP production resulting in an increase in TEF. To test this hypothesis, we measured the TEF of glucose solution with or without P in seven healthy subjects (3M 4F; Age=21.1±0.8y; BMI= 23.2 ±1.3kg/m2) in a cross over design with 1 week washout period. After a 10-h overnight fast, subjects drank a standardized 296mL solution containing 75g glucose, with P (500mg) or placebo pills. Oxygen consumption (VO2) was measured every 30 min for 3 hours. Baseline fasting resting metabolic rate (RMR) and VO2 did not differ between the 2 studies (1.2±0.2kcal/min and 250±37mL/min, respectively; p=0.92). Addition of P was associated with higher increase in VO2 (959±315 vs. 534±274 mL/60min; p= 0.03) which corresponded to higher TEF (5.7±1.6 vs. 3.6and±1.3kcal/60min; p=0.03 equivalent to 8% vs. 5% increase from RMR) during the first 60 min. VO2 and TEF did not differ between the studies afterwards. In conclusion, postprandial energy expenditure was further stimulated after drinking glucose solution with than without P. These results highlight the role of P in energy expenditure and thus energy balance. en_US
dc.language.iso en en_US
dc.title Phosphorus supplementation increases thermic response to glucose solution in healthy lean subjects en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201102356 en_US
dc.author.idnumber 201000400 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal The FASEB Journal en_US
dc.journal.volume 27 en_US
dc.journal.issue Supplement 1 en_US
dc.identifier.ctation Bassil, M., Zeeni, N., & Obeid, O. (2013). Phosphorus supplementation increases thermic response to glucose solution in healthy lean subjects. The FASEB Journal, 27(1 Supplement), 854-10. en_US
dc.author.email mbassil@lau.edu.lb en_US
dc.author.email nadine.zeeni@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.fasebj.org/doi/abs/10.1096/fasebj.27.1_supplement.854.10 en_US
dc.author.affiliation Lebanese American University en_US

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