Safety and efficacy of a ten day helicobacter pylori eradication regimen with rabeprazole, amoxicillin and clarithromycin. (c2003)

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dc.contributor.author Farchoukh, Lina
dc.contributor.author Haidar, Cyrine-Eliana
dc.date.accessioned 2011-10-13T12:23:17Z
dc.date.available 2011-10-13T12:23:17Z
dc.date.copyright 2003 en_US
dc.date.issued 2011-10-13
dc.date.submitted 2003-07-03
dc.identifier.uri http://hdl.handle.net/10725/769
dc.description Includes bibliographical references (leaves 56-64). en_US
dc.description.abstract OBJECTIVE: We assessed the safety and efficacy of a 1 a-day twice daily rabeprazole-based triple therapy for Helicobacler pylori (H .pylon). METHODS: H. pylori infected patients as confirmed by a rapid urease test were enrolled in an outpatient based open-label prospective trial. Symptomatic H. pylori infected patients were assigned to receive amoxicillin 1000 mg, clarithromycin 500 mg and rabeprazole 20 mg all twice daily for 10 days. No maintenance therapy was given during the follow up period. Patients were followed up during therapy by telephone calls to assess compliance and any occurrence of adverse effects. The efficacy endpoint was assessed by using the 14_C urea breath test (UBT). Occurrence of side effects was also evaluated. RESULTS: A total of 104 patients were analyzed per intention-to-treat (ITT) and per-protocol (PP). Eradication rates of 87.5% (ITT) and 93.8% (PP) were obtained. Therapy was relatively well tolerated with minimal side effects. CONCLUSION: Rabeprazole-based triple therapy is a suitable regimen for eradication of H. pylori infection. en_US
dc.language.iso en en_US
dc.subject Helicobacter pylori en_US
dc.subject Proton pump inhibitors en_US
dc.title Safety and efficacy of a ten day helicobacter pylori eradication regimen with rabeprazole, amoxicillin and clarithromycin. (c2003) en_US
dc.type Thesis en_US
dc.term.submitted Summer I en_US
dc.author.school Pharmacy en_US
dc.author.idnumber 199604220 en_US
dc.author.commembers Dr. Oussayma Moukhachen en_US
dc.author.commembers Dr. Shihadeh Nayfeh en_US
dc.author.commembers Dr. Assaad Soweid en_US
dc.author.woa OA en_US
dc.author.department Doctor of Pharmacy en_US
dc.description.physdesc 1 bound copy: xi, 64 leaves; ill. (some col.), map; 30 cm.; available at RNL. en_US
dc.author.division Pharmacy en_US
dc.author.advisor Dr. Gabriel Maliha en_US
dc.identifier.doi https://doi.org/10.26756/th.2003.10

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