Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice

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dc.contributor.author Shebaby, W.
dc.contributor.author El-Sibai, M.
dc.contributor.author Mroueh, M.
dc.contributor.author Bodman-Smith, K.
dc.contributor.author Taleb, R.
dc.contributor.author Daher, C.
dc.date.accessioned 2018-04-19T09:21:11Z
dc.date.available 2018-04-19T09:21:11Z
dc.date.copyright 2014 en_US
dc.date.issued 2018-04-19
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7425
dc.description.abstract The liver plays a major role in detoxifying and clearing xenobiotics that may lead to liver damage and hepatic dysfunction. The present study was carried out to evaluate the hepatoprotective activities of the chloroform-based fraction of wild carrot (Daucus carota L. ssp. carota; Apiacae) on CCl4-induced liver damage in BALB/c mice. Liver damage was induced by intraperitoneal injection of CCl4 at a dose of 1 ml/kg body weight. Animals were treated with different doses of the extract (50, 100 and 200 mg/kg body weight). Serum and liver homogenate supernatants were analyzed for marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. Pretreated groups with chloroform-based fraction reduced significantly the serum levels of AST and ALT. It also reversed the CCl4-induced decrease in SOD, CAT and GST levels thereby reducing significantly hepatic damage. HPLC analysis revealed that the chloroform-based fraction was rich in polyphenolic compounds such as luteolin, kaempferol, apigenin and quercetin, which could be partially responsible for the hepatoprotective effect. The current results suggest that chloroform-based fraction possess strong hepatoprotective activity against CCl4 induced liver damage at all doses used en_US
dc.language.iso en en_US
dc.title Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 200703859 en_US
dc.author.idnumber 199590020 en_US
dc.author.idnumber 200901968 en_US
dc.author.idnumber 199190130 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 80 en_US
dc.journal.issue 16 en_US
dc.article.pages P2O16 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0034-1395009 en_US
dc.identifier.ctation Shebaby, W., El-Sibai, M., Mroueh, M., Bodman-Smith, K., Taleb, R., & Daher, C. (2014). Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice. Planta Medica, 80(16), P2O16. en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.author.email robin.taleb@lau.edu.lb en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009 en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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