In vivo immunomodulatory effect of wild carrot oil and its fractions

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dc.contributor.author Taleb, RI
dc.contributor.author Shebaby, W.
dc.contributor.author Geha, M.
dc.contributor.author El-Sibai, M.
dc.contributor.author Mroueh, M.
dc.contributor.author Daher, CF
dc.date.accessioned 2018-04-19T09:09:21Z
dc.date.available 2018-04-19T09:09:21Z
dc.date.copyright 2015 en_US
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7424
dc.description.abstract Daucus carota L. ssp. carota (wild carrot) oil extract (DCOE) and fractions (F1, F2, F3 and F4) were recently shown to exhibit in vitro and in vivo anticancer activity [1,2]. The aim of this study is to examine the in vivo immunomodulatory effect of DCOE and its fractions on the levels of IFN-γ, TNF-α, IL-10, IL-17, and VEGF in spleen tissues of BALB/c mice. Animals were injected with 200 mg/Kg of DCOE or fractions and spleens were collected at 6 and 24 hrs post treatment. Whereas, DCOE and F1 did not induce a significant increase in IFN-γ levels at either interval, F2, F3, F4 and LPS caused 6.7, 4.6, 3.5 and 2.3 fold increases, respectively. The level of TNF-α displayed 2.4, 2.8, 6.2, 3.8, 2.5 and 3.1 fold increase compared to control 24 hrs post treatment with DCOE, F1, F2, F3, F4 and LPS, respectively. DCOE, F1 and F4 induced a 1.3 fold increase and F2 and F3 induced a 1.4 fold increase in the IL-10 levels, 6 hrs post treatment. However, no significant elevation of IL-10 was observed 24 hrs post injection of F2, F3 and F4 fractions. While 1.7, 1.6, and 1.75 fold increases in IL-17 were observed 6 hrs post treatment with F2, F3 and F4 respectively, these increments did not reach significance after 24 hrs. In addition, F1 and F2 were shown to inhibit the production levels of spleen VEGF. In conclusion, the in vivo antitumor activity of DCOE and fractions may be attributed to the enhancement of IFN-γ, TNF-α and IL-17 production and down regulation in the level of VEGF. en_US
dc.language.iso en en_US
dc.title In vivo immunomodulatory effect of wild carrot oil and its fractions en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 200901968 en_US
dc.author.idnumber 200703859 en_US
dc.author.idnumber 199590020 en_US
dc.author.idnumber 199190130 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 81 en_US
dc.journal.issue 16 en_US
dc.article.pages PM 67 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0035-1565444 en_US
dc.identifier.ctation Taleb, R. I., Shebaby, W., Geha, M., El-Sibai, M., Mroueh, M. A., & Daher, C. F. (2015). In vivo immunomodulatory effect of wild carrot oil and its fractions. Planta Medica, 81(16), PM_67. en_US
dc.author.email robin.taleb@lau.edu.lb en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1565444 en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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