Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma

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dc.contributor.author Shebaby, W.
dc.contributor.author Daher, G.
dc.contributor.author Taleb, R.
dc.contributor.author Daaboul, H.
dc.contributor.author El Sibai, M.
dc.contributor.author Mroueh, M.
dc.contributor.author Daher, CF
dc.date.accessioned 2018-04-19T08:46:40Z
dc.date.available 2018-04-19T08:46:40Z
dc.date.copyright 2015 en_US
dc.date.issued 2018-04-19
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7423
dc.description.abstract Daucus carota L. ssp. carota (wild carrot) was recently shown to exhibit in vitro and in vivo anticancer activities [1, 2]. DCOE was chromatographed to yield F1 (pentane; 100%), F2 (pentane-diethyl ether; 50:50), F3 (diethyl ether; 100%) and F4 (chloroform-methanol; 93:7) fractions. The fractions were tested in vitro against several cancer cell lines and F1 was found to possess the highest activity. Therefore, the present study aimed to evaluate its activity using the DMBA/TPA skin carcinogenesis model in mice. Skin papilloma were initiated by DMBA and promoted by TPA. F2 was administered to three experimental groups (10 mg/kg, 50 mg/kg, 200 mg/kg) via intraperitoneal injections thirty min prior to TPA promotion for a period of 21 weeks. Papilloma incidence, yield, and volume were compared with those of a non-treated control group. Treatment with F2 caused an inhibition in papilloma incidence, being highest (50%) at a dose of 200 mg/kg at the end of the experiment (week 21). Also, there was a dose-dependent decrease in papilloma yield during the study period. Additionally, F2 treatment with the three doses significantly decreased the papilloma volume at weeks 15, 18 and 21 (p < 0.05, p < 0.01 and p < 0.01, respectively). In conclusion, these findings clearly demonstrate that F2 has a remarkable antitumor activity against DMBA-TPA induced skin cancer and suggest the need for further studies to isolate the active chemotherapeutic agent. en_US
dc.language.iso en en_US
dc.title Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 201408580 en_US
dc.author.idnumber 200901968 en_US
dc.author.idnumber 200703859 en_US
dc.author.idnumber 199590020 en_US
dc.author.idnumber 199190130
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 81 en_US
dc.journal.issue 16 en_US
dc.article.pages PW 106 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0035-1565730 en_US
dc.identifier.ctation Shebaby, W., Daher, G., Taleb, R., Daaboul, H., El Sibai, M., Mroueh, M., & Daher, C. F. (2015). Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma. Planta Medica, 81(16), PW_106. en_US
dc.author.email wassim.shebaby@lau.edu.lb en_US
dc.author.email robin.taleb@lau.edu.lb en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.author.email cdaher@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1565730 en_US
dc.orcid.id https://orcid.org/0000-0002-9782-1870 en_US
dc.orcid.id https://orcid.org/0000-0001-8033-6951 en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.orcid.id https://orcid.org/0000-0003-1572-7133 en_US
dc.orcid.id https://orcid.org/0000-0002-8275-7263
dc.author.affiliation Lebanese American University en_US

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