The antitumor promoting activity of 2-himachalen-7-ol in two-stage mouse skin carcinogenesis test

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dc.contributor.author Daher, CF
dc.contributor.author Iskandar, RJ
dc.contributor.author Dib El Jalbout, NO
dc.contributor.author Dwairi, VF
dc.contributor.author Zgheib, MC
dc.contributor.author Ibrahim, MC
dc.contributor.author Saad, JMC
dc.contributor.author Chelala, NF
dc.contributor.author Daou, CP
dc.contributor.author Sawma Awad, LJ
dc.contributor.author Hakim, J.
dc.contributor.author Taleb, R.
dc.contributor.author El Sibai, M.
dc.contributor.author Mroueh, M.
dc.date.accessioned 2018-04-19T08:01:08Z
dc.date.available 2018-04-19T08:01:08Z
dc.date.copyright 2016 en_US
dc.date.issued 2018-04-19
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7420
dc.description.abstract Cedrus libani ssp. libani (Pinaceae) is a plant used in traditional medicine for the treatment of various diseases. 2-Himachalene-7-ol, previously isolated from the plant, possesses in vitro anticancer activity [1]. The present study investigates the chemopreventive effects of 2-himachalene-7-ol on 7,12-dimethyl benz(a)anthracene (DMBA)/12-O-tetradecanoyl phorobol-13-acetate (TPA) skin tumorigenesis model in mice. The stem xylem was extracted with hexane and the obtained oil was subjected to silica gel chromatography to isolate 2-himachalen-7-ol. Papilloma were initiated on shaved dorsal skin using DMBA and promoted twice weekly using TPA for 20 weeks [2]. Animal groups were treated once weekly with 2-himachalen-7-ol via different routes: gavage (50 mg/kg), intraperitoneally (IP 10, 25, or 50 mg/kg) or topically (0.2mL of 0.5, 1 or 2.5%). Tumor yield, and volume were compared with those of non-treated control and cisplatinum-treated groups (IP 2.5 mg/kg). Liver and kidney toxicity as well as body weight changes were also investigated. Data were analysed using ANOVA. At week 16 all animal groups treated with either 2-himachalen-7-ol or cisplatinum had relatively less papilloma number (0 – 52%) and volume (30 – 66%; p < 0.05). At week 20 the number of papilloma was highest in the cisplatinum and lowest in the 2-himachalen-7-ol IP 10 mg/kg groups. Inhibition of papilloma volume was maximal in the 2-himachalen-7-ol IP 25, IP 50 and gavage (48 – 52%; p < 0.01) followed by IP 10 and topical 2.5% (43%: p < 0.05) then cisplatinum (28%; NS) groups. The least gain in body weight was observed with the cisplatinum group. Liver enzymes (ALP, ALT and AST) were not affected in all treated groups; however creatinine and urea levels were significantly higher (p < 0.05) in the cisplatinum group compared to control. In conclusion, 2-himachalen-7-ol has potent antitumor activity against DMBA/TPA skin carcinogenesis with relatively lower toxicity than commonly used chemotherapeutic drugs. en_US
dc.language.iso en en_US
dc.title The antitumor promoting activity of 2-himachalen-7-ol in two-stage mouse skin carcinogenesis test en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020 en_US
dc.author.idnumber 200703859 en_US
dc.author.idnumber 200901968 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 82 en_US
dc.journal.issue S01 en_US
dc.article.pages P994 en_US
dc.keywords 2-himachalen-7-ol, en_US
dc.keywords Cancer en_US
dc.keywords Cedrus libani en_US
dc.keywords Skin carcinogenesis en_US
dc.keywords Papilloma en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0036-1596978 en_US
dc.identifier.ctation Daher, C. F., Iskandar, R. J., El Jalbout, N. D., Dwairi, V. F., Zgheib, M. C., Ibrahim, P. T., ... & Lteif, C. S. (2016). The antitumor promoting activity of 2-himachalen-7-ol in two-stage mouse skin carcinogenesis test. Planta Medica, 82(S 01), P994. en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.author.email mirvat.elsibai@lau.edu.lb en_US
dc.author.email robin.taleb@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1596978 en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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