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Salvia officinalis water extract: a potential hypolipidemic, hypoglycemic and anti-ulcerogenic remedy

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dc.contributor.author Daher, C
dc.contributor.author Mroueh, M
dc.contributor.author Alayan, I
dc.date.accessioned 2018-04-18T13:08:57Z
dc.date.available 2018-04-18T13:08:57Z
dc.date.copyright 2010 en_US
dc.date.issued 2018-04-18
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7416
dc.description.abstract Herbal medicine, an aspect of folk medicine, is nowadays practiced extensively in the community and most often without control when it comes to third world countries. Sage (Salvia officinalis L., Lamiaceae), widely used in folk medicine [1], is one of the medicinal herbs commonly used in the Middle East. The present investigation explores and sheds light on possible medicinal effects of the aqueous extract of sage leaves upon lipemia, glycemia and gastric ulcer in rats. After one month of extract intake via drinking water (50, 200 and 500mg/kg body weight), the highest dose showed significant improvement in serum HDL cholesterol, LDL/HDL cholesterol, and glucose. All doses used caused significant decreases in stool water content indicating that the extract is a possible remedy for patients with diarrhea. Assessment of liver enzyme activities (AST, ALT, LDH, ALP) revealed no hepatotoxic effects. Protection against ethanol-induced gastric ulcer [2] was investigated using 100 and 500mg/kg body weight doses. Results showed significant protection with both doses used. A maximum protection (46%) was observed at 100mg/kg body weight dose compared to the reference drug cimetidine (34%) at a dose of 10mg/kg body weight. The assessment of antibacterial activity against 11 bacterial hospital isolates using disk diffusion technique showed no potential in this respect. In conclusion, Salvia officinalis leaves water extract showed no liver toxicity, and exhibited a positive effect on lipemia, glycemia and gastric ulcer protection. en_US
dc.language.iso en en_US
dc.title Salvia officinalis water extract: a potential hypolipidemic, hypoglycemic and anti-ulcerogenic remedy en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 76 en_US
dc.journal.issue 12 en_US
dc.article.pages P625 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0030-1264923 en_US
dc.identifier.ctation Alayan, I., Mroueh, M., & Daher, C. (2010). Salvia officinalis water extract: a potential hypolipidemic, hypoglycemic and anti-ulcerogenic remedy. Planta Medica, 76(12), P625. en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0030-1264923 en_US
dc.author.affiliation Lebanese American University en_US


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