Prevention of carcinogen-induced mouse skin papilloma by Daucus carota (wild carrot) aqueous extract

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dc.contributor.author Daher, C
dc.contributor.author Mroueh, M
dc.contributor.author El Ghaziri, F
dc.date.accessioned 2018-04-18T12:49:18Z
dc.date.available 2018-04-18T12:49:18Z
dc.date.copyright 2011 en_US
dc.date.issued 2015-10-28
dc.identifier.issn 1439-0221 en_US
dc.identifier.uri http://hdl.handle.net/10725/7413
dc.description.abstract Daucus carota L. ssp. carota is a part of the folk medicine in Lebanon where it is used to enhance immunity and protect against many ailments among which are inflammation, gastric ulcer, and diabetes. Earlier we reported anti-inflammatory and anti-ulcer activities of the aqueous and methanolic extracts of the wild carrot umbels.1 Additionally, the aqueous extract of D.carota was found to possess anticancer activity against human promyelocytic leukemia HL-60 cells2, while the oil extract exhibited chemopreventive effect against chemically induced skin cancer.3 The present study investigates the anticancer effects of the aqueous extract of D. carota umbels on DMBA-induced skin cancer in mice. The extract was administered to animals via either gavage or intraperitoneal routes for 20 weeks. Significant antitumor effects were observed with the intraperitoneal (250mg/kg body weight) mode of treatment, where the percentage of papilloma incidence, yield and volume were reduced by 28, 23 and 86.4% respectively. Gavage treatment failed to inhibit tumor incidence, yield and volume. Intraperitoneal treatment decreased hyperplasia and dermal infiltration with an increase in the level of hyperkeratosis. These findings demonstrate that Daucus carota aqueous extract possesses anti-tumor activity against DMBA-induced skin cancer. en_US
dc.language.iso en en_US
dc.title Prevention of carcinogen-induced mouse skin papilloma by Daucus carota (wild carrot) aqueous extract en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP en_US
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Planta Medica en_US
dc.journal.volume 77 en_US
dc.journal.issue 12 en_US
dc.article.pages PF77 en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0031-1282465 en_US
dc.identifier.ctation Mroueh, M., El Ghaziri, F., & Daher, C. (2011). Prevention of carcinogen-induced mouse skin papilloma by Daucus carota (wild carrot) aqueous extract. Planta Medica, 77(12), PF77. en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1282465 en_US
dc.author.affiliation Lebanese American University en_US

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