DJ-1/PARK7 protein

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dc.contributor.editor Ariga, Hiroyoshi
dc.contributor.editor Iguchi-Ariga, Sanae M. M.
dc.date.accessioned 2017-12-21T08:16:48Z
dc.date.available 2017-12-21T08:16:48Z
dc.date.copyright 2017 en_US
dc.date.issued 2017-12-21
dc.identifier.isbn 9789811065835
dc.identifier.uri http://hdl.handle.net/10725/6849
dc.description.abstract DJ-1 and its prokaryotic homologs, Hsp31, YhbO and YajL from Escherichia coli and PfpI from Pyrococcus furiosus, repair proteins from glycation by glyoxals (R-CO-CHO), which constitute their major glycating agents. Glycation is a non-enzymatic covalent reaction discovered by Louis Camille Maillard in 1912, between reactive carbonyls (reducing sugars and glyoxals) and amino acids (cysteine, arginine and lysine), which inactivates proteins. By degrading Maillard adducts formed between carbonyls and thiols or amino groups, the DJ-1 family Maillard deglycases prevent the formation of the so-called advanced glycation end products (AGEs) that arise from Maillard adducts after dehydrations, oxidations and rearrangements. Since glycation is involved in ageing, cancer, atherosclerosis and cataracts, as well as post-diabetic, neurovegetatives and renal and autoimmune diseases, the DJ-1 deglycases are likely to play an important role in preventing these diseases. These deglycases, especially those from thermophilic organisms, may also be used to prevent the formation of dietary AGEs during food processing, sterilization and storage. They also prevent acrylamide formation in food, likely by degrading the asparagine/glyoxal Maillard adducts responsible for its formation. Since Maillard adducts are the substrates of the DJ-1 family deglycases, we propose renaming them Maillard deglycases. en_US
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Advances in experimental medicine and biology en_US
dc.subject Proteins en_US
dc.subject Nervous system -- Degeneration -- Molecular aspects en_US
dc.title DJ-1/PARK7 protein en_US
dc.type Book / Chapter of a Book en_US
dc.title.subtitle Parkinson's disease, cancer and oxidative stress-induced diseases en_US
dc.author.school SOP en_US
dc.author.idnumber 200703820 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.physdesc 1 online resource (224 pages) en_US
dc.publication.place Singapore en_US
dc.keywords Glycation en_US
dc.keywords Glyoxal en_US
dc.keywords Methylglyoxal en_US
dc.keywords Advanced glycation end products en_US
dc.keywords Maillard adducts en_US
dc.keywords Carbonyl stress en_US
dc.keywords Parkinson en_US
dc.keywords Diabetes en_US
dc.keywords Protein repair en_US
dc.keywords Acrylamide en_US
dc.description.bibliographiccitations Includes bibliographical references. en_US
dc.identifier.doi https://doi.org/10.1007/978-981-10-6583-5 en_US
dc.identifier.ctation Mihoub, M., Abdallah, J., & Richarme, G. (2017). Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases. In DJ-1/PARK7 Protein (pp. 133-147). Springer, Singapore. en_US
dc.chapter.author Mihoub, Mouadh
dc.chapter.author Abdallah, Jad
dc.chapter.author Richarme, Gilbert
dc.author.email jabdallah@lau.edu.lb en_US
dc.chapter.pages 133-147 en_US
dc.chapter.title Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/book/10.1007/978-981-10-6583-5 en_US
dc.orcid.id https://orcid.org/0000-0001-5267-4953 en_US
dc.publication.date 2017 en_US
dc.author.affiliation Lebanese American University en_US
dc.relation.numberofseries v. 1037

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