ABCB1 (P-glycoprotein) and blood-brain barrier

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dc.contributor.author Milane, Aline
dc.contributor.author Vautier, S.
dc.contributor.author Fernandez, C.
dc.date.accessioned 2017-12-20T10:42:26Z
dc.date.available 2017-12-20T10:42:26Z
dc.date.copyright 2006 en_US
dc.date.issued 2017-12-20
dc.identifier.issn 1952-4064 en_US
dc.identifier.uri http://hdl.handle.net/10725/6846
dc.description.abstract ABCB1 (MDR1/P-glycoprotein) is an ATP-dependant transmenbrane protein widely expressed in human organs, protecting them against xenobiotics. ABCB1 is involved in drug pharmacokinetics: at the blood-brain barrier level, due to its luminal localisation, ABCB1 limits drug transport and plays an important role in central detoxification. Many interindividual variabilities have been described on ABCB1 expression and functionality. Variabilities may play a role in the pathogenesis in neurological diseases. Furthermore, ABCB1 expression and/or functionality may modify drug efficacity or increase central adverse events. This paper reviews the implication of ABCB1 in the physiopathogenesis of neurological diseases and its role in the cerebral distribution of drugs. en_US
dc.language.iso en en_US
dc.title ABCB1 (P-glycoprotein) and blood-brain barrier en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle role in neurological diseases and their treatments en_US
dc.author.school SOP en_US
dc.author.idnumber 200904164 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal de Pharmacie Clinique en_US
dc.journal.volume 25 en_US
dc.journal.issue 4 en_US
dc.article.pages 225-235 en_US
dc.identifier.doi http://dx.doi.org/10.1684/jpc.2006.0021 en_US
dc.identifier.ctation Vautier, S., Fernandez, C., Milane, A., Lacomblez, L., Davrinche, C., & Farinotti, R. (2006). ABCB 1 (P-glycoprotein) and blood-brain barrier: role in neurological diseases and their treatments. JOURNAL DE PHARMACIE CLINIQUE, 25(4), 225. en_US
dc.author.email aline.milane@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.google.com.lb/search?q=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&oq=ABCB+1+(P-glycoprotein)+and+blood-brain+barrier%3A+role+in+neurological+diseases+and+their+treatments&aqs=chrome..69i57j69i60l2.431j0j8&sourceid=chrome&ie=UTF-8 en_US
dc.author.affiliation Lebanese American University en_US

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