Simple liquid chromatographic determination of minocycline in brain and plasma

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dc.contributor.author Milane, A.
dc.contributor.author Fernandez, C.
dc.contributor.author Bensimon, G.
dc.contributor.author Meininger, V.
dc.date.accessioned 2017-12-20T10:22:12Z
dc.date.available 2017-12-20T10:22:12Z
dc.date.copyright 2007 en_US
dc.date.issued 2017-12-20
dc.identifier.issn 1612-1112 en_US
dc.identifier.uri http://hdl.handle.net/10725/6845
dc.description.abstract A new high-performance liquid chromatography assay was developed for the determination of minocycline in plasma and brain. A solid–liquid extraction procedure was coupled with a reversed-phase HPLC system. The system requires a mobile phase consisting of acetonitrile:water:perchloric acid (26:74:0.25, v/v/v) adjusted to pH 2.5 with 5 M sodium hydroxide for elution through a RP8 column (250 × 3.0 mm, i.d.) with UV detection set at 350 nm. The method proved to be accurate, precise (RSD < 20%) and linear between 0.15–20 μg mL−1 in plasma and 1–20 μg mg−1 in brain. The method was successfully applied to a blood-brain barrier minocycline transport study. en_US
dc.language.iso en en_US
dc.title Simple liquid chromatographic determination of minocycline in brain and plasma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 200904164 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Chromatographia en_US
dc.journal.volume 65 en_US
dc.journal.issue 5-6 en_US
dc.article.pages 277-281 en_US
dc.keywords Column liquid chromatography en_US
dc.keywords Tetracycline antibiotics en_US
dc.keywords Minocycline in blood and brain en_US
dc.identifier.ctation Milane, A., Fernandez, C., Bensimon, G., Meininger, V., & Farinotti, R. (2007). Simple liquid chromatographic determination of minocycline in brain and plasma. Chromatographia, 65(5-6), 277-281. en_US
dc.author.email aline.milane@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1365/s10337-006-0167-5 en_US
dc.author.affiliation Lebanese American University en_US

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