Brain cancer stem cells in adults and children

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dc.contributor.author Abou-Antoun, Tamara J.
dc.contributor.author Hale, James S.
dc.contributor.author Lathia, Justin D.
dc.contributor.author Dombrowski, Stephen M.
dc.date.accessioned 2017-12-18T10:00:12Z
dc.date.available 2017-12-18T10:00:12Z
dc.date.copyright 2017 en_US
dc.date.issued 2017-12-18
dc.identifier.issn 1878-7479 en_US
dc.identifier.uri http://hdl.handle.net/10725/6822
dc.description.abstract Brain tumors represent some of the most malignant cancers in both children and adults. Current treatment options target the majority of tumor cells but do not adequately target self-renewing cancer stem cells (CSCs). CSCs have been reported to resist the most aggressive radiation and chemotherapies, and give rise to recurrent, treatment-resistant secondary malignancies. With advancing technologies, we now have a better understanding of the genetic, epigenetic and molecular signatures and microenvironmental influences which are useful in distinguishing between distinctly different tumor subtypes. As a result, efforts are now underway to identify and target CSCs within various tumor subtypes based on this foundation. This review discusses progress in CSC biology as it relates to targeted therapies which may be uniquely different between pediatric and adult brain tumors. Studies to date suggest that pediatric brain tumors may benefit more from genetic and epigenetic targeted therapies, while combination treatments aimed specifically at multiple molecular pathways may be more effective in treating adult brain tumors which seem to have a greater propensity towards microenvironmental interactions. Ultimately, CSC targeting approaches in combination with current clinical therapies have the potential to be more effective owing to their ability to compromise CSCs maintenance and the mechanisms which underlie their highly aggressive and deadly nature. en_US
dc.language.iso en en_US
dc.title Brain cancer stem cells in adults and children en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle cell biology and therapeutic implications en_US
dc.author.school SOP en_US
dc.author.idnumber 201005279 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Neurotherapeutics en_US
dc.journal.volume 14 en_US
dc.journal.issue 2 en_US
dc.article.pages 372-384 en_US
dc.keywords Cancer stem cells en_US
dc.keywords Childhood brain tumors en_US
dc.keywords Glioblastoma en_US
dc.keywords Epigenetics en_US
dc.keywords Microenvironment en_US
dc.keywords Therapeutic implications en_US
dc.identifier.doi http://dx.doi.org/10.1007/s13311-017-0524-0 en_US
dc.identifier.ctation Abou-Antoun, T. J., Hale, J. S., Lathia, J. D., & Dombrowski, S. M. (2017). Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications. Neurotherapeutics, 372-384. en_US
dc.author.email tamara.abouantoun@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1007/s13311-017-0524-0 en_US
dc.author.affiliation Lebanese American University en_US

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