The effects of Salvia Officinalis leave on hyperlipidemia, glycemia, ulcer, inflammation, and bactericidal activity. (c2006)

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dc.contributor.author Alayan, Iman
dc.date.accessioned 2011-09-29T08:34:15Z
dc.date.available 2011-09-29T08:34:15Z
dc.date.copyright 2006 en_US
dc.date.issued 2011-09-29
dc.date.submitted 2006-06-07
dc.identifier.uri http://hdl.handle.net/10725/656
dc.description Includes bibliographical references (leaves 57-64). en_US
dc.description.abstract Salvia Ojficinalis plants, commonly known as Sage, possess a wide range of biological activities. Although many studies were conducted on S. Ojficinalis, the research interest in S. Officinalis plant is still justifiable because of its reputed medicinal value. The purpose of this study is to evaluate the efficacy of the aqueous extract of S. Officinalis leaves on blood lipid profile, glycemia, liver enzymes, gastric ulcer, inflammation and bactericidal activity. After one month of water extract intake (42, 167 and 420 mg/kg body weight) in drinking water in concomitance with a high fat diet, rats showed an increase in serum HDL cholesterol levels, but significance was reached at the highest dose only. This was accompanied with a small but important decrease in LDL cholesterol when the 167 and 420 mg/kg body weight doses were used. The extract also exhibited a dose dependent decrease in serum glucose level, where significance was attained at the highest dose. However, serum insulin was not significantly different from the control group. Extract intake did not appear to affect stool triglyceride and cholesterol content except for a significant decrease in cholesterol observed with the highest dose. At all doses, the extract, reduced significantly the water content in the stools of rats. Assessment of liver enzyme activities assured that the extract has no hepatotoxic effects over the study period. S. Officinalis leaves aqueous extract (l00 and 500 mg/Kg body weight) also exhibited a significant anti-ulcerogenic effect against ethanol-induced gastric ulcer, an inhibition comparable to that exerted by cimetidine, a proton pump inhibitor drug. Also, the extract (100, 250 and 500 mg/lg body weight) showed a significant anti-inflammatory effect in cases of both acute and chronic inflammation induced by carrageenan and formalin respectively. No anti-bacterial effect was observed with the different concentrations used. In conclusion, S. Officinalis leaves aqueous extract has a beneficial impact upon lipidemia, glycemia, and inflammation, and it plays a minor protective role against gastric ulcer. The extract can also be used as a remedy for the treatment of diarrhea. en_US
dc.language.iso en en_US
dc.subject Salvia en_US
dc.subject Salvia -- Therapeutic use en_US
dc.subject Sage en_US
dc.subject Medicine, Herbal en_US
dc.title The effects of Salvia Officinalis leave on hyperlipidemia, glycemia, ulcer, inflammation, and bactericidal activity. (c2006) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school Arts and Sciences en_US
dc.author.idnumber 199911490 en_US
dc.author.commembers Dr. George Baroody
dc.author.commembers Dr. Roy Khalaf
dc.author.woa OA en_US
dc.description.physdesc 1 bound copy: xvi, 64 leaves; ill. (some col.); 31 cm. available at RNL. en_US
dc.author.division Biology en_US
dc.author.advisor Dr. Costantine Daher
dc.identifier.doi https://doi.org/10.26756/th.2006.30 en_US
dc.publisher.institution Lebanese American University en_US

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