Combined 585 nm pulsed-dye and 1,064 nm Nd

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dc.contributor.author Tannous, Zeina
dc.contributor.author Shofner, Joshua D.
dc.contributor.author Jalian, Ray H.
dc.contributor.author Avram, Mathew M.
dc.contributor.author Stankiewicz, Kelly J.
dc.date.accessioned 2017-11-10T07:36:59Z
dc.date.available 2017-11-10T07:36:59Z
dc.date.copyright 2014 en_US
dc.identifier.issn 1096-9101 en_US
dc.identifier.uri http://hdl.handle.net/10725/6569
dc.description.abstract Background and Objective Basal cell carcinomas (BCCs) have supporting vasculature that serves as a target for vascular selective lasers. The objective of this study was to determine the effect of repeated treatment with a combined 585 nm pulsed dye laser (PDL) and 1,064 nm Neodymium Yttrium Aluminum Garnet (Nd:YAG) laser on BCCs of superficial and nodular subtypes of varying diameters. Study Design/Materials and Methods Ten subjects with 13 biopsy-proven BCCs received four combined PDL and Nd:YAG at treatments 2–4 week intervals. None of the BCCs met the criteria for Mohs micrographic surgery. The tumor and 4 mm of peripheral skin were treated using standardized parameters delivered with a 7 mm spot with 10% overlap. The treated area was excised and evaluated histologically for residual tumor. The primary study endpoint was histologic clearance of tumor. The secondary study endpoint was blinded investigator assessment of clinical endpoint and adverse effects. Results Approximately half of all tumors showed a complete response to four combined PDL and Nd:YAG treatments (n = 7/12, 58%). When stratified by size, 75% of all tumors <1 cm in diameter (n = 6/8) showed complete response. Tumor histologic types among the complete responders included superficial and nodular BCCs. All subjects with incompletely responding BCCs were on various forms of anticoagulation, which we hypothesize, may inhibit laser-mediated thrombosis necessary for the clinical effect. Blinded investigator assessment suggests that biopsy related erythema improves with subsequent laser treatments. Conclusions Combined PDL and Nd:YAG laser is an effective means of reducing tumor burden in patients with BCC and may be a promising, emerging alternative therapy. Factors influencing treatment response includes the concomitant use of anticoagulation. Further studies are needed to investigate and optimize the utility of this treatment protocol. Lasers Surg. Med. 46:1–7, 2014. © 2013 Wiley Periodicals, Inc. en_US
dc.language.iso en en_US
dc.title Combined 585 nm pulsed-dye and 1,064 nm Nd en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle YAG lasers for the treatment of basal cell carcinoma en_US
dc.author.school SOM en_US
dc.author.idnumber 201100706 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Lasers in Surgery and Medicine en_US
dc.journal.volume 46 en_US
dc.journal.issue 1 en_US
dc.article.pages 1-7 en_US
dc.identifier.doi http://dx.doi.org/1002/lsm.22201 en_US
dc.identifier.ctation Jalian, H., Avram, M. M., Stankiewicz, K. J., Shofner, J. D., & Tannous, Z. (2014). Combined 585 nm pulsed‐dye and 1,064 nm Nd: YAG lasers for the treatment of basal cell carcinoma. Lasers in surgery and medicine, 46(1), 1-7. en_US
dc.author.email zeina.tannous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/lsm.22201/full en_US
dc.author.affiliation Lebanese American University en_US

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