Selective photothermolysis to target sebaceous glands

LAUR Repository

Show simple item record

dc.contributor.author Tannous, Zeina
dc.contributor.author Sakamoto, Fernanda H.
dc.contributor.author Doukas, Apostolos G.
dc.contributor.author Farinelli, William A.
dc.contributor.author Williams, Gwyn P.
dc.contributor.author Anderson, Rox R.
dc.contributor.author Dylla, Frederick H.
dc.contributor.author Gubeli III, Joseph F.
dc.date.accessioned 2017-11-08T13:07:47Z
dc.date.available 2017-11-08T13:07:47Z
dc.date.copyright 2012 en_US
dc.date.issued 2017-11-08
dc.identifier.issn 1096-9101 en_US
dc.identifier.uri http://hdl.handle.net/10725/6563
dc.description.abstract Background and Objectives The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH2 vibrational absorption wavelength band. Methods Absorption spectra of natural and artificially prepared sebum were measured from 200 to 3,000 nm, to determine wavelengths potentially able to target sebaceous glands. The Jefferson National Accelerator superconducting FEL was used to measure photothermal excitation of aqueous gels, artificial sebum, pig skin, human scalp, and forehead skin (sebaceous sites). In vitro skin samples were exposed to FEL pulses from 1,620 to 1,720 nm, spot diameter 7–9.5 mm with exposure through a cold 4°C sapphire window in contact with the skin. Exposed and control tissue samples were stained using H&E, and nitroblue tetrazolium chloride staining (NBTC) was used to detect thermal denaturation. Results Natural and artificial sebum both had absorption peaks near 1,210, 1,728, 1,760, 2,306 and 2,346 nm. Laser-induced heating of artificial sebum was approximately twice that of water at 1,710 and 1,720 nm, and about 1.5× higher in human sebaceous glands than in water. Thermal camera imaging showed transient focal heating near sebaceous hair follicles. Histologically, skin samples exposed to ∼1,700 nm, ∼100–125 milliseconds pulses showed evidence of selective thermal damage to sebaceous glands. Sebaceous glands were positive for NBTC staining, without evidence of selective loss in samples exposed to the laser. Epidermis was undamaged in all samples. Conclusions SP of sebaceous glands appears to be feasible. Potentially, optical pulses at ∼1,720 or ∼1,210 nm delivered with large beam diameter and appropriate skin cooling in approximately 0.1 seconds may provide an alternative treatment for acne. Lasers Surg. Med. 44:175–183, 2012. © 2012 Wiley Periodicals, Inc. en_US
dc.language.iso en en_US
dc.title Selective photothermolysis to target sebaceous glands en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle theoretical estimation of parameters and preliminary results using a free electron laser en_US
dc.author.school SOM en_US
dc.author.idnumber 201100706 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Lasers in Surgery and Medicine en_US
dc.journal.volume 44 en_US
dc.journal.issue 2 en_US
dc.article.pages 175-183 en_US
dc.identifier.doi http://dx.doi.org/10.1002/lsm.21132 en_US
dc.identifier.ctation Sakamoto, F. H., Doukas, A. G., Farinelli, W. A., Tannous, Z., Shinn, M., Benson, S., ... & Anderson, R. (2012). Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers in surgery and medicine, 44(2), 175-183. en_US
dc.author.email zeina.tannous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/lsm.21132/full en_US
dc.author.affiliation Lebanese American University en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account