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The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas

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dc.contributor.author Tannous, Zeina S.
dc.contributor.author Konnikov, Nellie
dc.contributor.author Shah, Sonali M.
dc.contributor.author Duncan, Lyn M.
dc.date.accessioned 2017-11-08T10:05:11Z
dc.date.available 2017-11-08T10:05:11Z
dc.date.copyright 2009 en_US
dc.identifier.issn 1096-9101 en_US
dc.identifier.uri http://hdl.handle.net/10725/6550
dc.description.abstract Background and Objective Basal cell carcinomas (BCCs) have supporting vasculature that could serve as a target for 595 nm pulsed dye laser (PDL). The objective of this study was to determine the effect of repeated PDL treatments on BCCs of superficial and nodular subtypes and of varying diameters. Study Design/Materials and Methods Twenty biopsy-proven BCCs received four 595 nm PDL treatments at 2-week intervals. The tumor and 4 mm of peripheral skin were treated using a set of previously optimized laser parameters: one pass, 15 J/cm2 energy, 3 ms pulse length, no cooling, and 7 mm spot size with 10% overlap. The treated area was excised and evaluated histologically for residual tumor. Histologic response rates of the PDL treated BCCs were compared with that of non-PDL treated, matched control tumors. Results Nearly all BCCs <1.5 cm in diameter (n = 12) showed complete response to four PDL treatments (91.7%; n = 11/12) versus 16.7% of controls (n = 2/12, P-value = 0.0003). BCCs ≥1.5 cm in diameter (n = 8) showed a complete response rate of 25% (n = 2/8) versus 0% of controls (n = 0/8, P-value = 0.2). Mean clinical tumor diameter of the complete responders was 1.1 cm (n = 13) versus 2.2 cm (n = 7) for incomplete responders (P-value = 0.005). Tumor histologic types among the complete responders included superficial, nodular, micronodular, and keratinizing. Incompletely responding BCCs showed a significant reduction in tumor burden after PDL treatment, with residual histologic tumor burden ranging from <1% to 29% of the original clinical tumor diameter, compared to 13–68% residual tumor burden for the corresponding controls (P-value = 0.05). Conclusions PDL is an effective means of reducing tumor burden in patients with large BCCs and may be an alternative therapy in BCCs <1.5 cm in diameter. Lasers Surg. Med. 41:417–422, 2009. © 2009 Wiley-Liss, Inc. en_US
dc.language.iso en en_US
dc.title The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100706 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Lasers in Surgery and Medicine en_US
dc.journal.volume 41 en_US
dc.journal.issue 6 en_US
dc.article.pages 417-422 en_US
dc.identifier.doi http://dx.doi.org/10.1002/lsm.20787 en_US
dc.identifier.ctation Shah, S. M., Konnikov, N., Duncan, L. M., & Tannous, Z. S. (2009). The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Lasers in surgery and medicine, 41(6), 417-422. en_US
dc.author.email zeina.tannous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/lsm.20787/full en_US
dc.author.affiliation Lebanese American University en_US


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