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Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type

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dc.contributor.author Tannous, Zeina
dc.contributor.author Lerner, Lisa H.
dc.contributor.author Duncan, Lyn M.
dc.contributor.author Mihim, Martin C.
dc.contributor.author Flotte, Thomas
dc.date.accessioned 2017-11-08T09:24:22Z
dc.date.available 2017-11-08T09:24:22Z
dc.date.copyright 2000 en_US
dc.identifier.issn 1532-8392 en_US
dc.identifier.uri http://hdl.handle.net/10725/6544
dc.description.abstract We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of the cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This fording supports the distinction of these entities and may have therapeutic implications. en_US
dc.language.iso en en_US
dc.title Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100706 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type en_US
dc.journal.volume 31 en_US
dc.journal.issue 6 en_US
dc.article.pages 705-708 en_US
dc.keywords Lentigo maligna melanoma en_US
dc.keywords Lentigo maligna en_US
dc.keywords Tumor progression en_US
dc.identifier.doi https://doi.org/10.1053/hupa.2000.7640 en_US
dc.identifier.ctation Tannous, Z. S., Lerner, L. H., Duncan, L. M., Mihm, M. C., & Flotte, T. J. (2000). Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type. Human pathology, 31(6), 705-708. en_US
dc.author.email zeina.tannous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0046817700801136 en_US
dc.author.affiliation Lebanese American University en_US


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