Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma

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dc.contributor.author Tannous, Zeina
dc.contributor.author Gonzalez, Salvador
dc.date.accessioned 2017-11-08T07:53:07Z
dc.date.available 2017-11-08T07:53:07Z
dc.date.copyright 2002 en_US
dc.date.issued 2017-11-08
dc.identifier.issn 2352-5126 en_US
dc.identifier.uri http://hdl.handle.net/10725/6534
dc.description.abstract Background: Real-time, near-infrared confocal laser scanning microscopy may provide a way to diagnose basal cell carcinoma in vivo and might potentially eliminate the need for invasive diagnostic biopsies in the future. Objective: The purpose of this study is to define the in vivo histologic features of basal cell carcinoma by using a high-resolution imaging technique. Methods: Five fair-skinned white patients with 8 basal cell carcinoma lesions were recruited for this study. Near-infrared reflectance confocal microscopy imaging was used to characterize the histologic features of these lesions in vivo. Subsequently, the confocal histologic features were correlated with the corresponding routine hematoxylin-and-eosin-stained sections obtained from invasive biopsies. Results: A uniform population of basal cell carcinoma cells with characteristic elongated nuclei oriented along the same axis was always present. Abundant blood vessels demonstrating prominent tortuosity were seen, as well as prominent, predominantly mononuclear inflammatory infiltrate admixed or in close apposition with basal cell carcinoma cells. Trafficking of leukocytes was visualized in real time. Conclusion: Our results demonstrate that near-infrared confocal microscopy may facilitate diagnosis of basal cell carcinoma with the use of in vivo high-resolution confocal features. Accuracy studies to evaluate these in vivo histologic criteria are warranted. (J Am Acad Dermatol 2002;47:869-74.) en_US
dc.language.iso en en_US
dc.title Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100706 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the American Academy of Dermatology en_US
dc.journal.volume 47 en_US
dc.journal.issue 6 en_US
dc.article.pages 869-874 en_US
dc.identifier.doi https://doi.org/10.1067/mjd.2002.124690 en_US
dc.identifier.ctation González, S., & Tannous, Z. (2002). Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma. Journal of the American Academy of Dermatology, 47(6), 869-874. en_US
dc.author.email zeina.tannous@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S019096220200316X en_US
dc.author.affiliation Lebanese American University en_US

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