Phototoxicity of strained Ru(II) complexes

Azar, Daniel F.; Audi, Hassib; Farhat, Stephanie; El-Sibai, Mirvat; Abi-Habib, Ralph J.; Khnayzer, Rony S.

Phototoxicity of strained Ru(II) complexes

Azar, Daniel F.; Audi, Hassib; Farhat, Stephanie; El-Sibai, Mirvat; Abi-Habib, Ralph J.; Khnayzer, Rony S.

URI: http://hdl.handle.net/10725/6499

URL: http://pubs.rsc.org/-/content/articlehtml/2017/dt/c7dt02255g

DOI: http://dx.doi.org/10.1039/C7DT02255G

Date: 2017-11-03

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Abstract:

A photochemically dissociating ligand in Ru(bpy)2(dmphen)Cl2 [bpy = 2,2′-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)2(H2O)22+ and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(II) complexes.

Citation:

Azar, D. F., Audi, H., Farhat, S., El-Sibai, M., Abi-Habib, R. J., & Khnayzer, R. S. (2017). Phototoxicity of strained Ru (ii) complexes: is it the metal complex or the dissociating ligand?. Dalton Transactions, 46(35), 11529-11532.