The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas

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dc.contributor.author Abou-Ghazal, Mohamed
dc.contributor.author Yang, David S.
dc.contributor.author Qiao, Wei
dc.contributor.author Reina-Ortiz, Chantal
dc.contributor.author Wei, Jun
dc.contributor.author Kong, Ling-Yuan
dc.contributor.author Fuller, Gregory N.
dc.contributor.author Hiroka, Nobuyoshi
dc.contributor.author Priebe, Waldemar
dc.contributor.author Sawaya, Raymond
dc.contributor.author Heimberger, Amy B.
dc.date.accessioned 2017-11-02T07:35:16Z
dc.date.available 2017-11-02T07:35:16Z
dc.date.copyright 2008 en_US
dc.date.issued 2017-11-02
dc.identifier.issn 1557-3265 en_US
dc.identifier.uri http://hdl.handle.net/10725/6473
dc.description.abstract Purpose: The signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in most cancers, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients. We sought to determine the incidence of phosphorylated STAT3 (p-STAT3) expression in malignant gliomas of different pathologic types, whether p-STAT3 expression is a negative prognostic factor, and whether p-STAT3 expression influences the inflammatory response within gliomas. Methods: Using immunohistochemical analysis, we measured the incidence of p-STAT3 expression in 129 patients with gliomas of various pathologic types in a glioma tissue microarray. We categorized our results according to the total number of p-STAT3–expressing cells within the gliomas and correlated this number with the number of infiltrating T cells and T regulatory cells. We then evaluated the association between p-STAT3 expression and median survival time using univariate and multivariate analyses. Results: We did not detect p-STAT3 expression in normal brain tissues or low-grade astrocytomas. We observed significant differences in the incidence of p-STAT3 expression between the different grades of astrocytomas and different pathologic glioma types. p-STAT3 expression was associated with the population of tumor-infiltrating immune cells but not with that of T regulatory cells. On univariate analysis, we found that p-STAT3 expression within anaplastic astrocytomas was a negative prognostic factor. Conclusions: p-STAT3 expression is common within gliomas of both the astrocytic and oligodendroglial lineages and portends poor survival in patients with anaplastic astrocytomas. p-STAT3 expression differs significantly between gliomas of different pathologic types and grades and correlated with the degree of immune infiltration. en_US
dc.language.iso en en_US
dc.title The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201303847 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Clinical Cancer Research en_US
dc.journal.volume 14 en_US
dc.journal.issue 24 en_US
dc.article.pages 8228-8235 en_US
dc.identifier.doi http://dx.doi.org/10.1158/1078-0432.CCR-08-1329 en_US
dc.identifier.ctation Abou-Ghazal, M., Yang, D. S., Qiao, W., Reina-Ortiz, C., Wei, J., Kong, L. Y., ... & Heimberger, A. B. (2008). The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clinical Cancer Research, 14(24), 8228-8235. en_US
dc.author.email mohamed.aboughazal@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://clincancerres.aacrjournals.org/content/14/24/8228.short en_US
dc.author.affiliation Lebanese American University en_US

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