Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas

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dc.contributor.author Abou-Ghazal, Mohamed
dc.contributor.author Heimberger, Amy B.
dc.contributor.author Reina-Ortiz, Chantal
dc.contributor.author Yang, David S.
dc.contributor.author Sun, Wei
dc.contributor.author Qiao, Wei
dc.contributor.author Hiraoka, Nobuyoshi
dc.contributor.author Fuller, Gregory N.
dc.date.accessioned 2017-11-02T07:22:32Z
dc.date.available 2017-11-02T07:22:32Z
dc.date.copyright 2008 en_US
dc.date.issued 2017-11-02
dc.identifier.issn 1557-3265 en_US
dc.identifier.uri http://hdl.handle.net/10725/6472
dc.description.abstract Purpose: The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset of patients with gliomas. Our hypothesis is that only the most malignant gliomas have a prominent glioma-infiltrating Treg population that contributes to the immunosuppressive biology and that the presence of Tregs is a negative prognostic variable. Experimental Design: We measured the incidence of Tregs in 135 glial tumors (including all pathologic types) in a glioma microarray using immunohistochemical analysis. Results were categorized according to the total number ofTregs within the tumors. Correlation of the presence of Tregs with prognosis was evaluated using univariate and multivariate analyses. Results: Tregs were not present in normal brain tissue and were very rarely found in low-grade gliomas and oligodendrogliomas.We observed significant differences in the prevalence of Tregs between astrocytic and oligodendroglial tumors, between tumors of different grades, and between different pathologic types of tumors. We identified Tregs most frequently in glioblastoma multiforme (GBM) but very rarely in low-grade astrocytomas. The presence of Tregs within GBMs did not alter the median survival in patients from whom the tumors were obtained. Conclusions:Treg infiltration differed significantly in the tumors according to lineage, pathology, and grade.Tregs seemed to have the highest predilection for tumors of the astrocytic lineage and specifically in the high-grade gliomas, such as GBM. In both univariate and multivariate analysis, the presence of Tregs in GBMs seemed to be prognostically neutral. en_US
dc.language.iso en en_US
dc.title Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201303847 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Clinical Cancer Research en_US
dc.journal.volume 14 en_US
dc.journal.issue 16 en_US
dc.article.pages 5166-5172 en_US
dc.identifier.doi http://dx.doi.org/10.1158/1078-0432.CCR-08-0320 en_US
dc.identifier.ctation Heimberger, A. B., Abou-Ghazal, M., Reina-Ortiz, C., Yang, D. S., Sun, W., Qiao, W., ... & Fuller, G. N. (2008). Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas. Clinical Cancer Research, 14(16), 5166-5172. en_US
dc.author.email mohamed.aboughazal@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://clincancerres.aacrjournals.org/content/14/16/5166.short en_US
dc.author.affiliation Lebanese American University en_US

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