Role of cytokines and platelet-activating factor in inflammatory bowel disease

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dc.contributor.author Nassif, Anis
dc.contributor.author Longo, Walter E.
dc.contributor.author Mazuski, John E.
dc.contributor.author Vernava, Anthony M.
dc.contributor.author Kaminski, Donald L.
dc.date.accessioned 2017-11-01T07:28:37Z
dc.date.available 2017-11-01T07:28:37Z
dc.date.copyright 1996 en_US
dc.identifier.issn 1530-0358 en_US
dc.identifier.uri http://hdl.handle.net/10725/6446
dc.description.abstract BACKGROUND: Platelet-activating factor (PAF) and cytokines, such as interleukins, tumor necrosis factor, and others, are thought to play a role in the inflammatory process involving gastrointestinal disorders such as Crohn's disease, ulcerative colitis, ischemic colitis, or antibiotic-associated colitis. PURPOSE: This study was undertaken to review the latest literature on the role of PAF and cytokines in the genesis of inflammatory bowel disease and implications for therapy and management. RESULTS: PAF is an endogenous phospholipid involved in hypersensitivity and inflammatory reactions such as platelet and neutrophil aggregation, vasodilation, increased vascular permeability, and leukocyte adhesion, which have been associated with inflammatory processes. Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. CONCLUSIONS: Because PAF and cytokines may have an important role in the pathogenesis of inflammatory bowel disease, their inhibition by specific antagonists, mediators, or other agents such as steroids may have a potential therapeutic benefit in treatment and management of these inflammatory diseases in the near future. en_US
dc.language.iso en en_US
dc.title Role of cytokines and platelet-activating factor in inflammatory bowel disease en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201306054 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Diseases of the Colon & Rectum en_US
dc.journal.volume 39 en_US
dc.journal.issue 2 en_US
dc.article.pages 217-223 en_US
dc.identifier.ctation Nassif, A., Longo, W. E., Mazuski, J. E., Vernava, A. M., & Kaminski, D. L. (1996). Role of cytokines and platelet-activating factor in inflammatory bowel disease. Diseases of the colon & rectum, 39(2), 217-223. en_US
dc.author.email anis.nassif@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/article/10.1007%2FBF02068079?LI=true en_US
dc.author.affiliation Lebanese American University en_US

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