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Health-related quality of life in adults with transfusion-independent thalassaemia intermedia compared to regularly transfused thalassaemia major

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dc.contributor.author Abi-Habib, Rudy
dc.contributor.author Khoury, Brigitte
dc.contributor.author Musallam, Khaled M.
dc.contributor.author Bazzi, Lama
dc.contributor.author Succar, Julien
dc.contributor.author Halawi, Racha
dc.contributor.author Hamkir, Ahmed
dc.contributor.author Koussa, Suzanne
dc.contributor.author Taher, Ali T.
dc.date.accessioned 2017-10-23T10:52:38Z
dc.date.available 2017-10-23T10:52:38Z
dc.date.copyright 2011 en_US
dc.identifier.issn 1600-0609 en_US
dc.identifier.uri http://hdl.handle.net/10725/6409
dc.description.abstract Background: In patients with β thalassaemia intermedia (TI), the milder anaemia and transfusion independence imply better health-related quality of life (HR-QoL). However, the unbalanced pathophysiology of the disease allows for several serious clinical complications to manifest, which may have a negative impact on HR-QoL. Methods: This was a cross-sectional study on adult patients with transfusion- and iron chelation-independent TI and β thalassaemia major (TM) attending the Chronic Care Center, Hazmieh, Lebanon. A total of 80 patients agreed to participate in the study [32 TI (median age 24 yr) and 48 TM (median age 23 yr)]. The RAND SF-36 survey was used to assess HR-QoL. Data on patient demographics, clinical complications and socioeconomic status were collected. Results: Patients with TI and TM were comparable with age and gender, but patients with TM had a significantly longer median duration with a known thalassaemia diagnosis. Patients with TI had a higher proportion of multiple complications. Socioeconomic parameters were comparable, except for patients with TI being more commonly married. The mean Total, Physical Health and Mental Health Scores were significantly lower in patients with TI compared to TM, indicating poorer HR-QoL. There was a statistically significant positive correlation between the duration with a known thalassaemia diagnosis and a higher Mental Health Score (rs = 0.73, P = 0.020). The mean Physical Health Score was significantly lower in patients with multiple clinical complications compared to patients with single or no complications (P = 0.012). Associations remained independently significant at multivariate analysis. Conclusion: Patients with transfusion-independent TI have lower HR-QoL compared to TM patients. At a comparable age, the shorter duration since diagnosis and the multiplicity of complications may explain these findings. en_US
dc.language.iso en en_US
dc.title Health-related quality of life in adults with transfusion-independent thalassaemia intermedia compared to regularly transfused thalassaemia major en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle new insights en_US
dc.author.school SAS en_US
dc.author.idnumber 201400035 en_US
dc.author.department Social Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal European Journal of Haematology en_US
dc.journal.volume 87 en_US
dc.journal.issue 1 en_US
dc.article.pages 73-79 en_US
dc.keywords Thalassaemia intermedia en_US
dc.keywords Thalassaemia major en_US
dc.keywords Chronic disease en_US
dc.keywords Quality of life en_US
dc.keywords Clinical complications en_US
dc.keywords Health-related quality of life en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1600-0609.2011.01623.x en_US
dc.identifier.ctation Musallam, K. M., Khoury, B., Abi‐Habib, R., Bazzi, L., Succar, J., Halawi, R., ... & Taher, A. T. (2011). Health‐related quality of life in adults with transfusion‐independent thalassaemia intermedia compared to regularly transfused thalassaemia major: new insights. European journal of haematology, 87(1), 73-79. en_US
dc.author.email rudy.abihabib@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01623.x/epdf en_US
dc.author.affiliation Lebanese American University en_US


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