Functional localization of cAMP signalling in cardiac myocytes

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dc.contributor.author Vandecasteele, G.
dc.contributor.author Rochais, F.
dc.contributor.author Abi-Gerges, A.
dc.contributor.author Fischmeister, R.
dc.date.accessioned 2017-10-19T13:01:59Z
dc.date.available 2017-10-19T13:01:59Z
dc.date.copyright 2006 en_US
dc.date.issued 2017-10-19
dc.identifier.issn 1470-8752 en_US
dc.identifier.uri http://hdl.handle.net/10725/6364
dc.description.abstract The cAMP pathway is of cardinal importance for heart physiology and pathology. The spatial organization of the various components of the cAMP pathway is thought to allow the segregation of functional responses triggered by the different neuromediators and hormones that use this pathway. PDEs (phosphodiesterases) hydrolyse cAMP (and cGMP) and play a major role in this process by preventing cAMP diffusion to the whole cytosol and inadequate target activation. The development of olfactory cyclic nucleotide-gated channels to directly monitor cAMP beneath the plasma membrane in real time allows us to gain new insights into the molecular mechanisms responsible for cAMP homoeostasis and hormonal specificity in cardiac cells. The present review summarizes the recent results we obtained using this approach in adult rat ventricular myocytes. In particular, the role of PDEs in the maintenance of specific cAMP signals generated by β-adrenergic receptors and other Gs-coupled receptors will be discussed. en_US
dc.language.iso en en_US
dc.title Functional localization of cAMP signalling in cardiac myocytes en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201402416 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Biochemical Society Transactions en_US
dc.journal.volume 34 en_US
dc.journal.issue 4 en_US
dc.article.pages 484-488 en_US
dc.keywords Adrenergic receptor en_US
dc.keywords cAMP en_US
dc.keywords Cardiac myocyte en_US
dc.keywords Cyclic nucleotide-gated channel (CNG channel) en_US
dc.keywords G-protein-coupled receptor en_US
dc.keywords Phosphodiesterase (PDE) en_US
dc.identifier.doi https://doi.org/10.1042/BST0340484 en_US
dc.identifier.ctation Vandecasteele, G., Rochais, F., Abi-Gerges, A., & Fischmeister, R. (2006). Functional localization of cAMP signalling in cardiac myocytes. Biochemical Society Transactions, 34 (4). en_US
dc.author.email aniella.abigerges@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://europepmc.org/article/med/16856839 en_US
dc.orcid.id https://orcid.org/0000-0001-9974-4023 en_US
dc.author.affiliation Lebanese American University en_US

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