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Electronic spectra and electronic structures of some antimicrobials derived from proflavine

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dc.contributor.author Capomacchia, Anthony C.
dc.contributor.author Schulman, Stephen G.
dc.contributor.author Naik, Datta V.
dc.contributor.author Roy, Timothy
dc.date.accessioned 2017-10-18T05:53:57Z
dc.date.available 2017-10-18T05:53:57Z
dc.date.copyright 1975 en_US
dc.identifier.issn 1520-6017 en_US
dc.identifier.uri http://hdl.handle.net/10725/6337
dc.description.abstract The shifts in the absorption and fluorescence spectra of 3-aminoacridine, proflavine, acridine orange, and acridine yellow were employed to show that the singly charged cations, the predominant species at biological pH, exist in the ground state in the amino form. In the lowest excited singlet state, however, the monocations of the diaminoacridines have the imino structure, a conclusion supported by the relative ground- and excited-state pKa values of the reactions of the monocation with H+. The ground-state amino structure has its positive charge concentrated at the heterocyclic nitrogen atom, a fact that is of primary importance in determining the geometry of binding to DNA. en_US
dc.language.iso en en_US
dc.title Electronic spectra and electronic structures of some antimicrobials derived from proflavine en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201408778 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Pharmaceutical Sciences en_US
dc.journal.volume 64 en_US
dc.journal.issue 6 en_US
dc.article.pages 982-986 en_US
dc.identifier.doi http://dx.doi.org/10.1002/jps.2600640619 en_US
dc.identifier.ctation Schulman, S. G., Naik, D. V., Capomacchia, A. C., & Roy, T. (1975). Electronic spectra and electronic structures of some antimicrobials derived from proflavine. Journal of pharmaceutical sciences, 64(6), 982-986. en_US
dc.author.email anthony.capomacchia@lau.ed.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/jps.2600640619/full en_US
dc.author.affiliation Lebanese American University en_US


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