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Valence tautomerism of singly protonated 9-aminoacridine and its implications for intercalative interactions with nucleic acids

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dc.contributor.author Capomacchia, Anthony C.
dc.contributor.author Casper, Jay
dc.contributor.author Schulman, Stephen G.
dc.date.accessioned 2017-10-17T11:42:23Z
dc.date.available 2017-10-17T11:42:23Z
dc.date.copyright 1974 en_US
dc.identifier.issn 1520-6017 en_US
dc.identifier.uri http://hdl.handle.net/10725/6334
dc.description.abstract Electronic absorption and fluorescence spectroscopy were used to show that the singly protonated 9-aminoacridine cation exists as the vinylogous cyclic amidine valence tautomer, the 9-iminoacridan monocation, in ground and excited states when in aqueous solution at physiological pH. The evidence indicates that the 9-aminoacridine monocation may intercalate into double-helical DNA in an orientation different from that employed by other acridine derivatives. en_US
dc.language.iso en en_US
dc.title Valence tautomerism of singly protonated 9-aminoacridine and its implications for intercalative interactions with nucleic acids en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201408778 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Pharmaceutical Sciences en_US
dc.journal.volume 63 en_US
dc.journal.issue 8 en_US
dc.article.pages 1272-1276 en_US
dc.identifier.doi http://dx.doi.org/10.1002/jps.2600630823 en_US
dc.identifier.ctation Capomacchia, A. C., Casper, J., & Schulman, S. G. (1974). Valence tautomerism of singly protonated 9‐aminoacridine and its implications for intercalative interactions with nucleic acids. Journal of pharmaceutical sciences, 63(8), 1272-1276. en_US
dc.author.email anthony.capomacchia@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/jps.2600630823/full en_US
dc.author.affiliation Lebanese American University en_US


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