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Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus

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dc.contributor.author Capomacchia, A.C.
dc.contributor.author Collier, Jarrod W.
dc.contributor.author Thakare, Mohan
dc.contributor.author Ahmed, Hisham
dc.contributor.author Graner, Solomon T.
dc.contributor.author Israel, Bridgette
dc.contributor.author Granade, Saundra
dc.date.accessioned 2017-10-17T11:19:06Z
dc.date.available 2017-10-17T11:19:06Z
dc.date.copyright 2008 en_US
dc.identifier.issn 1097-9867 en_US
dc.identifier.uri http://hdl.handle.net/10725/6332
dc.description.abstract Theophylline controlled release capsules (THEO-24 CR) were used as a model system to evaluate accelerated dissolution tests for process and quality control and formulation development of controlled release formulations. Dissolution test acceleration was provided by increasing temperature, pH, flow rate, or adding surfactant. Electron microscope studies on the theophylline microspheres subsequent to each experiment showed that at pH values of 6.6 and 7.6 the microspheres remained intact, but at pH 8.6 they showed deterioration. As temperature was increased from 37–57°C, no change in microsphere integrity was noted. Increased flow rate also showed no detrimental effect on integrity. The effect of increased temperature was determined to be the statistically significant variable. en_US
dc.language.iso en en_US
dc.title Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201408778 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmaceutical Development and Technology en_US
dc.journal.volume 14 en_US
dc.journal.issue 1 en_US
dc.article.pages 9-17 en_US
dc.identifier.doi http://dx.doi.org/10.1080/10837450802409362 en_US
dc.identifier.ctation Collier, J. W., Thakare, M., Garner, S. T., Israel, B. E., Ahmed, H., Granade, S., ... & Capomacchia, A. C. (2009). Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus. Pharmaceutical development and technology, 14(1), 9-17. en_US
dc.author.email anthony.capomacchia@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.1080/10837450802409362 en_US
dc.author.affiliation Lebanese American University en_US


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