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Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres

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dc.contributor.author Capomacchia, Anthony C.
dc.contributor.author Thakare, Mohan
dc.contributor.author Graner, Solomon T.
dc.contributor.author Ahmed, Hisham
dc.contributor.author Graner, Pamela
dc.contributor.author Elder, Deborah
dc.contributor.author Price, James C.
dc.contributor.author Israel, Bridgette
dc.date.accessioned 2017-10-17T11:03:08Z
dc.date.available 2017-10-17T11:03:08Z
dc.date.copyright 2011 en_US
dc.identifier.issn 1097-9867 en_US
dc.identifier.uri http://hdl.handle.net/10725/6330
dc.description.abstract Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a xanthine bronchodilator was used to model controlled release owing to its narrow therapeutic index. Microspheres were prepared using different ratios of dual surfactant in an emulsion-solvent evaporation process. Drug loading, encapsulation efficiency, particle size distribution, and geometric mean diameters were evaluated. Drug release was evaluated using several kinetic models including zero and first order, Higuchi square root, and Hixson-Crowell. Microspheres presented as mostly spherical particles and diffusional drug release was affected by microsphere construction. For this novel, dual surfactant system the microsphere matrix is a hydrophobic polymer and the release rate may be modulated with variation in ratio of dual surfactants. Dissolution data followed the Higuchi model and supports the formation of a monolithic microsphere matrix that releases theophylline by Fickian diffusion. Dual surfactants for preparation of microspheres are an inadequately studied research area that offers another means to modulate particle size and drug release. For the current study microspheres prepared with surfactant ratios of Span 65: Tween 40 between 3:1 and 2:1 provided the best control of size and drug release. en_US
dc.language.iso en en_US
dc.title Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle effect of different dual surfactant ratios en_US
dc.author.school SOP en_US
dc.author.idnumber 201408778 en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmaceutical Development and Technology en_US
dc.journal.volume 18 en_US
dc.journal.issue 5 en_US
dc.article.pages 1213-1219 en_US
dc.keywords Dual surfactants en_US
dc.keywords CHLB en_US
dc.keywords Ethyl cellulose microspheres en_US
dc.keywords Emulsion solvent evaporation en_US
dc.keywords Dissolution en_US
dc.keywords Drug release mechanism en_US
dc.identifier.doi http://dx.doi.org/10.3109/10837450.2011.620969 en_US
dc.identifier.ctation Thakare, M., Israel, B., Garner, S. T., Ahmed, H., Garner, P., Elder, D., ... & Capomacchia, A. C. (2013). Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres: effect of different dual surfactant ratios. Pharmaceutical development and technology, 18(5), 1213-1219. en_US
dc.author.email anthony.capomacchia@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.3109/10837450.2011.620969 en_US
dc.author.affiliation Lebanese American University en_US


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