Toxicity assessment of industrial chemicals and airborne contaminants

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dc.contributor.author Khalil, C.
dc.contributor.author Hayes, A.
dc.contributor.author Winder, C.
dc.contributor.author Bakand, S.
dc.date.accessioned 2017-10-17T09:35:40Z
dc.date.available 2017-10-17T09:35:40Z
dc.date.copyright 2005 en_US
dc.date.issued 2017-10-17
dc.identifier.issn 1091-7691 en_US
dc.identifier.uri http://hdl.handle.net/10725/6326
dc.description.abstract Exposure to occupational and environmental contaminants is a major contributor to human health problems. Inhalation of gases, vapors, aerosols, and mixtures of these can cause a wide range of adverse health effects, ranging from simple irritation to systemic diseases. Despite significant achievements in the risk assessment of chemicals, the toxicological database, particularly for industrial chemicals, remains limited. Considering there are approximately 80,000 chemicals in commerce, and an extremely large number of chemical mixtures, in vivo testing of this large number is unachievable from both economical and practical perspectives. While in vitro methods are capable of rapidly providing toxicity information, regulatory agencies in general are still cautious about the replacement of whole-animal methods with new in vitro techniques. Although studying the toxic effects of inhaled chemicals is a complex subject, recent studies demonstrate that in vitro methods may have significant potential for assessing the toxicity of airborne contaminants. In this review, current toxicity test methods for risk evaluation of industrial chemicals and airborne contaminants are presented. To evaluate the potential applications of in vitro methods for studying respiratory toxicity, more recent models developed for toxicity testing of airborne contaminants are discussed. en_US
dc.language.iso en en_US
dc.title Toxicity assessment of industrial chemicals and airborne contaminants en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle transition from in vivo to in vitro test methods: a review en_US
dc.author.school SAS en_US
dc.author.idnumber 201408580 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Inhalation Toxicology en_US
dc.journal.volume 17 en_US
dc.journal.issue 13 en_US
dc.article.pages 775-787 en_US
dc.identifier.doi http://dx.doi.org/10.1080/08958370500225240 en_US
dc.identifier.ctation Bakand, S., Winder, C., Khalil, C., & Hayes, A. (2005). Toxicity assessment of industrial chemicals and airborne contaminants: transition from in vivo to in vitro test methods: a review. Inhalation Toxicology, 17(13), 775-787. en_US
dc.author.email christian.khalil@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.1080/08958370500225240 en_US
dc.author.affiliation Lebanese American University en_US

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