Surface water toxicity assessment by ecotoxicological and in vitro toxicologocical assays

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dc.contributor.author Khalil, C.
dc.contributor.author Winder, C.
dc.date.accessioned 2017-10-17T08:56:56Z
dc.date.available 2017-10-17T08:56:56Z
dc.date.copyright 2008 en_US
dc.date.issued 2017-10-17
dc.identifier.issn 1743-3541 en_US
dc.identifier.uri http://hdl.handle.net/10725/6323
dc.description.abstract Environmental pollution is an ever-growing problem in today’s consumer world. Disposal of chemicals and their unwanted by-products into the natural environment poses significant risks to ecosystems and human health. The receiving natural environment is a sink to chemical mixtures and this triggers a range of potential environmental and health problems. It is therefore imperative to develop rapid reliable techniques for initial screening and establishment of toxic potential and risks. The selection of the catchment study locations in Tasmania (creeks stream and rivers) was the result of recorded observations following rainfall of anomalous oyster population mortality and adverse human health in the geographical catchment area. A biological impact was identified in the study area but the casual agents and environmental triggers were unclear hence the need for in vitro toxicology assessment techniques for identifying the triggers and risks associated with exposure to environmental contaminants. The aim of this paper is to present findings of in vitro cytotoxicity assays and their potential in assessing contaminated river water toxicity using human cell cultures. The key to the approach adopted was to investigate exposure to the environmental pollutants and generate human toxicity profiles with a high degree of confidence using cell viability and damage as end points. Furthermore, correlation of the toxicity results using human cell cultures as ecological receptors in the study area clearly indicated the usefulness of and sensitivity of human-derived cells in detecting the toxicity of unknown chemical mixtures. Keywords: water samples, human skin cells, human skin fibroblasts, HepG2, A549, toxicity, cytotoxicity, ecotoxicity, MTS, sea urchin development test, bivalve larval development test. en_US
dc.language.iso en en_US
dc.title Surface water toxicity assessment by ecotoxicological and in vitro toxicologocical assays en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201408580 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal WIT Transactions on Ecology and the Environment en_US
dc.journal.volume 110 en_US
dc.article.pages 253-262 en_US
dc.keywords Water samples en_US
dc.keywords Human skin cells en_US
dc.keywords Human skin fibroblasts en_US
dc.keywords HepG2 en_US
dc.keywords A549 en_US
dc.keywords Toxicity en_US
dc.keywords Cytotoxicity en_US
dc.keywords Ecotoxicity en_US
dc.keywords MTS en_US
dc.keywords Sea urchin development test en_US
dc.keywords Bivalve larval development test en_US
dc.identifier.ctation Khalil, C., & Winder, C. (2008). Surface water toxicity assessment by ecotoxicological and in vitro toxicologocical assays. WIT Transactions on Ecology and the Environment, 110, 253-262. en_US
dc.author.email christian.khalil@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.witpress.com/elibrary/wit-transactions-on-biomedicine-and-health/110/19066 en_US
dc.author.affiliation Lebanese American University en_US

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