The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton

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dc.contributor.author Stephan, Joseph S.
dc.contributor.author Fioriti, Luana
dc.contributor.author Lamba, Nayan
dc.contributor.author Colnaghi, Luca
dc.contributor.author Karl, Kevin
dc.contributor.author Derkatch, Irna L.
dc.contributor.author Kandel, Eric R.
dc.date.accessioned 2017-09-22T09:11:03Z
dc.date.available 2017-09-22T09:11:03Z
dc.date.copyright 2015 en_US
dc.identifier.issn 2211-1247 en_US
dc.identifier.uri http://hdl.handle.net/10725/6238
dc.description.abstract The mouse cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a translational regulator implicated in long-term memory maintenance. Invertebrate orthologs of CPEB3 in Aplysia and Drosophila are functional prions that are physiologically active in the aggregated state. To determine if this principle applies to the mammalian CPEB3, we expressed it in yeast and found that it forms heritable aggregates that are the hallmark of known prions. In addition, we confirm in the mouse the importance of CPEB3’s prion formation for CPEB3 function. Interestingly, deletion analysis of the CPEB3 prion domain uncovered a tripartite organization: two aggregation-promoting domains surround a regulatory module that affects interaction with the actin cytoskeleton. In all, our data provide direct evidence that CPEB3 is a functional prion in the mammalian brain and underline the potential importance of an actin/CPEB3 feedback loop for the synaptic plasticity underlying the persistence of long-term memory. en_US
dc.language.iso en en_US
dc.title The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201509224 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Cell Reports en_US
dc.journal.volume 11 en_US
dc.journal.issue 11 en_US
dc.article.pages 1772-1785 en_US
dc.identifier.doi https://doi.org/10.1016/j.celrep.2015.04.060 en_US
dc.identifier.ctation Stephan, J. S., Fioriti, L., Lamba, N., Colnaghi, L., Karl, K., Derkatch, I. L., & Kandel, E. R. (2015). The CPEB3 protein is a functional prion that interacts with the actin cytoskeleton. Cell reports, 11(11), 1772-1785. en_US
dc.author.email joseph.stephan@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S2211124715004921 en_US
dc.author.affiliation Lebanese American University en_US

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