The regulation of autophagy in eukaryotic cells

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dc.contributor.author Stephan, Joseph S.
dc.contributor.author Herman, Paul K.
dc.date.accessioned 2017-09-22T08:48:10Z
dc.date.available 2017-09-22T08:48:10Z
dc.date.copyright 2006 en_US
dc.date.issued 2017-09-22
dc.identifier.issn 1554-8635 en_US
dc.identifier.uri http://hdl.handle.net/10725/6236
dc.description.abstract The induction of autophagy appears to be tightly controlled in all eukaryotic cells. This highly conserved, degradative process is induced by a variety of signals, including nutrient deprivation, and is generally thought to be refractory to cell growth. Recent work in the budding yeast, Saccharomyces cerevisiae, has suggested that the Atg1 protein kinase is at the center of this control. Atg1, and its associated proteins, appear to be directly targeted by multiple signaling pathways important for the control of both autophagy and cell growth. These pathways involve the small GTP-binding Ras proteins, the Tor protein kinases and the AMP-activated protein kinase, Snf1, respectively. A key question that remains is whether this regulatory paradigm has been evolutionarily conserved. In other words, is Atg1 the primary target of those signalingpathways responsible for coordinating growth with environmental influences in other eukaryotes? Here, we suggest that Atg1 is very likely to fulfill this role but that a truly definitive answer will require that we develop a better understanding of this protein kinase and its targets in all eukaryotes. en_US
dc.language.iso en en_US
dc.title The regulation of autophagy in eukaryotic cells en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle do all roads pass through Atg1? en_US
dc.author.school SOM en_US
dc.author.idnumber 201509224 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Autophagy en_US
dc.journal.volume 2 en_US
dc.journal.issue 2 en_US
dc.article.pages 146-148 en_US
dc.keywords Autophagy en_US
dc.keywords CAMP-dependent protein kinase en_US
dc.keywords Tor proteins en_US
dc.keywords Snf1 protein kinase en_US
dc.keywords Atg1 en_US
dc.keywords Macroautophagy en_US
dc.keywords Pre-autophagosomal structure en_US
dc.identifier.doi http://dx.doi.org/10.4161/auto.2.2.2485 en_US
dc.identifier.ctation Stephan, J. S., & Herman, P. K. (2006). The regulation of autophagy in eukaryotic cells: do all roads pass through Atg1?. Autophagy, 2(2), 146-148. en_US
dc.author.email joseph.stephan@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.4161/auto.2.2.2485 en_US
dc.author.affiliation Lebanese American University en_US

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