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Symptoms of depression and anxiety in anorexia nervosa

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dc.contributor.author Mattar, Lama
dc.contributor.author Gauthier, Claire
dc.contributor.author Hassler, Christine
dc.contributor.author Launay, Jean-Marie
dc.contributor.author Callebert, Jacques
dc.contributor.author Steiger, Howard
dc.contributor.author Mechior, Jean-Claude
dc.date.accessioned 2017-09-15T12:57:18Z
dc.date.available 2017-09-15T12:57:18Z
dc.date.copyright 2014 en_US
dc.identifier.issn 1873-3360 en_US
dc.identifier.uri http://hdl.handle.net/10725/6209
dc.description.abstract Depressive, anxiety and obsessive symptoms frequently co-occur with anorexia nervosa (AN). The relationship between these clinical manifestations and the biological changes caused by starvation is not well understood. It has been hypothesised that reduced availability of tryptophan (TRP) could reduce serotonin activity and thus trigger these comorbid symptoms. The aim of this study, during re-feeding in individuals with AN, was to analyse covariations across measures of nutritional status, depressive and anxiety symptoms, and peripheral serotonin markers. Depressive and anxiety symptoms, nutritional status and serotonin markers – whole blood serotonin content, plasma TRP and the ratio between TRP and large neutral amino acids – were assessed for 42 AN participants at admission to inpatient treatment and after re-feeding. Biological measures were compared to those obtained in 42 non-eating disordered subjects. For those with AN, psychological, nutritional and biological parameters improved significantly during hospitalisation. Levels of serotonin markers were significantly lower in the AN group compared to the control group, at admission and at discharge. Increase in the TRP/LNAA ratio was correlated with a decrease in depressive symptoms. In addition, there was a positive correlation between serotonin levels and symptoms of both anxiety and depression at discharge. We speculate that enhanced TRP availability during re-feeding, as a result of the increase in the TRP/LNAA ratio, could restore serotonin neurotransmission and lead to a decrease in depressive symptoms. The association between serotonin and anxiety and depressive symptoms would be consistent with numerous observations indicating abnormal functioning of the serotoninergic system in AN en_US
dc.language.iso en en_US
dc.title Symptoms of depression and anxiety in anorexia nervosa
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle links with plasma tryptophan and serotonin metabolism
dc.author.school SAS en_US
dc.author.idnumber 201306205 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Psychoneuroendocrinology en_US
dc.journal.volume 39 en_US
dc.article.pages 170-178 en_US
dc.keywords Anorexia nervosa en_US
dc.keywords Anxiety en_US
dc.keywords Depression en_US
dc.keywords Malnutrition en_US
dc.keywords Serotonin en_US
dc.keywords Tryptophan en_US
dc.identifier.doi https://doi.org/10.1016/j.psyneuen.2013.09.009 en_US
dc.identifier.ctation Gauthier, C., Hassler, C., Mattar, L., Launay, J. M., Callebert, J., Steiger, H., ... & Lang, F. (2014). Symptoms of depression and anxiety in anorexia nervosa: Links with plasma tryptophan and serotonin metabolism. Psychoneuroendocrinology, 39, 170-178. en_US
dc.author.email lama.mattar@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0306453013003284 en_US
dc.author.affiliation Lebanese American University en_US


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